Medpedia

• Sarcoma, Ewing's

Inclusion Criteria:
-  CESS81/CESS86/EICESS92/EURO-E.W.I.N.G.99 trials participants of the German Society of
Pediatric Hematology and Oncology (GPOH)
Exclusion Criteria:
-  no complete remission (CR)
-  any kind of paralysis
-  <5y after diagnosis

Trial objective: As survival rates of bone sarcoma patients have been raised owing to
improved treatment strategies the focus of investigations is now on the medical, social, and
economic sequelae of intensive multimodal treatment. This study aims to assess the
functional outcome, quality of life and late sequelae in a representative sample of
long-term survivors of Ewing sarcoma. The data recorded combined with standardized treatment
data covering a 30-year period will produce a data pool that is unique for its magnitude and
will be used for the development of guidelines for further improvements of future bone
sarcoma treatment.

Working plan: The working plan provides for the assessment of functional outcome and quality
of life by means of validated tools (TESS, SF36, PEDQOL) and objectively measuring daily
activity patterns by using the Step Activity Monitor (SAM) in 1100 long-term Ewing sarcoma
survivors and a control group of 1100 matched healthy subjects. Information on sarcoma
treatment and follow-up is obtained by re-structuring and complementing the database of the
relevant patient cohort (n=3000) from four consecutive nationwide and international clinical
trials between 1980 and 2008. Procedures of local treatment will be evaluated regarding
functional outcome, quality of life, and survival probability and prognostic factors
predicting long-term outcome will be identified.

Exploitation of results: The results will be presented at scientific meetings and will be
published in international journals. Guidelines will be developed regarding improvements in
the treatment, rehabilitation, and social integration of bone sarcoma patients to be
utilized in guiding patients and in the decision process of medical professionals regarding
their treatment. In the long run, the evidence based guidelines on treatment and follow-up
are to be transferred into the health system.

• real-world daily activity (SAM: step-activity-monitor)
  5-30years after primary diagnosis of Ewing sarcoma
  Safety Issue: No
• health-related quality of life (SF36, PEDQOL)
  5-30years after primary diagnosis of Ewing sarcoma
  Safety Issue: No
• functional status (TESS)
  5-30years after primary diagnosis of Ewing sarcoma
  Safety Issue: No
• psychological status (HADS, BIS-BAS)
  5-30years after primary diagnosis of Ewing sarcoma
  Safety Issue: No

• Heribert Jürgens, Prof.
  Principal Investigator, University Hospital Muenster
• Dieter Rosenbaum, Prof.
  Principal Investigator, University Hospital Muenster

• Motion Analysis Lab, Orthopedic Department, University Hospital
  Münster, North Rhine Westphalia, 48129, Germany
  Recruiting
  Corinna Winter, MA

  49(251) 835-2975

  winterco@uni-muenster.de
  Dieter Rosenbaum, Prof.

  49(251) 835-2970

  diro@uni-muenster.de

  Investigators

  • Dieter Rosenbaum, Prof.
    Principal Investigator
• Department of Pediatric Hematology and Oncology, University Children's Hospital
  Muenster, North Rhine Westphalia, 48129, Germany
  Recruiting
  Andreas Ranft, Dr.

  49(251) 835-6486

  andreas.ranft@ukmuenster.de
  Christiane Hoffmann, Dr.

  49(251) 835-6485

  Christiane.Hoffmann@ukmuenster.de

  Investigators

  • Heribert Jürgens, Prof.
    Principal Investigator

• University Hospital Muenster
  Lead Sponsor
• Germany: Ethics Commission
• Germany: Federal Ministry of Education and Research

• Brandes M, Schomaker R, Möllenhoff G, Rosenbaum D. Quantity versus quality of gait and quality of life in patients with osteoarthritis. Gait Posture. 2008 Jul;28(1):74-9. Epub 2007 Nov 28.
• Gerber LH, Hoffman K, Chaudhry U, Augustine E, Parks R, Bernad M, Mackall C, Steinberg S, Mansky P. Functional outcomes and life satisfaction in long-term survivors of pediatric sarcomas. Arch Phys Med Rehabil. 2006 Dec;87(12):1611-7.
• Hoffmann C, Gosheger G, Gebert C, Jürgens H, Winkelmann W. Functional results and quality of life after treatment of pelvic sarcomas involving the acetabulum. J Bone Joint Surg Am. 2006 Mar;88(3):575-82.
• McDonald CM, Widman L, Abresch RT, Walsh SA, Walsh DD. Utility of a step activity monitor for the measurement of daily ambulatory activity in children. Arch Phys Med Rehabil. 2005 Apr;86(4):793-801.
• Nagarajan R, Neglia JP, Clohisy DR, Robison LL. Limb salvage and amputation in survivors of pediatric lower-extremity bone tumors: what are the long-term implications? J Clin Oncol. 2002 Nov 15;20(22):4493-501. Review.
• Paulussen M, Craft AW, Lewis I, Hackshaw A, Douglas C, Dunst J, Schuck A, Winkelmann W, Köhler G, Poremba C, Zoubek A, Ladenstein R, van den Berg H, Hunold A, Cassoni A, Spooner D, Grimer R, Whelan J, McTiernan A, Jürgens H; European Intergroup Cooperative Ewing's Sarcoma Study-92. Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients. J Clin Oncol. 2008 Sep 20;26(27):4385-93.
• Pieper S, Ranft A, Braun-Munzinger G, Jurgens H, Paulussen M, Dirksen U. Ewing's tumors over the age of 40: a retrospective analysis of 47 patients treated according to the International Clinical Trials EICESS 92 and EURO-E.W.I.N.G. 99. Onkologie. 2008 Dec;31(12):657-63. Epub 2008 Nov 20.
• Rödl RW, Hoffmann C, Gosheger G, Leidinger B, Jürgens H, Winkelmann W. Ewing's sarcoma of the pelvis: combined surgery and radiotherapy treatment. J Surg Oncol. 2003 Jul;83(3):154-60.
• Rosenbaum D, Brandes M, Hardes J, Gosheger G, Rödl R. Physical activity levels after limb salvage surgery are not related to clinical scores-objective activity assessment in 22 patients after malignant bone tumor treatment with modular prostheses. J Surg Oncol. 2008 Aug 1;98(2):97-100.
• Schuck A, Ahrens S, Paulussen M, Kuhlen M, Könemann S, Rübe C, Winkelmann W, Kotz R, Dunst J, Willich N, Jürgens H. Local therapy in localized Ewing tumors: results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials. Int J Radiat Oncol Biol Phys. 2003 Jan 1;55(1):168-77.
• Song KM, Bjornson KF, Cappello T, Coleman K. Use of the StepWatch activity monitor for characterization of normal activity levels of children. J Pediatr Orthop. 2006 Mar-Apr;26(2):245-9.
• Weddington WW. Psychological outcomes in survivors of extremity sarcomas following amputation or limb-sparing surgery. Cancer Treat Res. 1991;56:53-60. Review. No abstract available.