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Displaying 1 to 10 out of 56 total clinical trials for "ewing sarcoma"

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  • Diagnostic Study of Tumor Characteristics in Patients With Ewing's Sarcoma
    RATIONALE: Genetic testing may help predict how cancer will respond to treatment and allow doctors to plan more effective therapy. PURPOSE: Diagnostic trial to study genetic differences in patients who have Ewing's sarcoma.
    Status: Active, not recruiting Location: New York, Texas, Tennessee, Wisconsin, California
  • Collecting and Storing Biological Samples From Patients With Ewing Sarcoma
    RATIONALE: Collecting and storing samples of tumor tissue, bone marrow, and blood from patients with cancer to test in the laboratory may help the study of cancer in the future. PURPOSE: This research study is collecting and storing samples of tumor tissue, bone marrow, and blood from patients with Ewing sarcoma.
    Status: Recruiting Location: Massachusetts, North Carolina, Tennessee, Calif...
  • Functional and Clinical Long-Term Outcome of Ewing Sarcoma Treatment
    The purpose of the study is to assess the functional outcome, quality of life and late sequelae in a representative sample of 1100 long-term survivors of Ewing sarcoma and to build a unique clinical and functional data pool of the underlying cohort of 3000 Ewing sarcoma patients with a follow-up of 3 decades.
    Status: Not yet recruiting Location: North Rhine Westphalia
  • Study in Localized and Disseminated Ewing Sarcoma
    Ewing Sarcoma Primary objectives: Standard Risk R1: in a randomised trial, to examine whether add-on treatment with fenretinide or zoledronic acid, or zoledronic acid plus fenretinide in addition to induction and maintenance chemotherapy improves event-free survival in patients with localised Ewing sarcoma and good histological response or with initial tumour vol...
    Status: Recruiting Phase 3 Location: Maryland
  • Irinotecan in Treating Patients With Newly Diagnosed Ewing's Sarcoma
    RATIONALE: Drugs used in chemotherapy, such as irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. PURPOSE: This phase II trial is studying how well irinotecan works in treating patients with newly diagnosed Ewing's sarcoma.
    Status: Completed Phase 2 Location: England
  • Prognostic Value of a Positive RT-PCR Test in Patients With Ewing Sarcoma
    This study will determine whether the results of a test called reverse transcriptase-polymerase chain reaction (RT-PCR) correlate with clinical outcomes in patients with Ewing sarcoma, and if they can be used to help identify patients at high risk for metastasis (spread of the cancer beyond the original site). This is a companion study to another NCI trial (AEWS0031), w...
    Status: Completed Location: Maryland
  • Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma
    RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one drug with surgery and radiation therapy may kill more tumor cells. It is not yet known which combination chemotherapy regimen is most effective in treating patients...
    Status: Active, not recruiting Phase 3 Location: England
  • Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing's Sarcoma or Neuroectodermal Tumor
    RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which chemotherapy regimen combined with radiation therapy and/or surgery is more effective in treating Ewing's sarcoma or primitive neuroectodermal tumor. P...
    Status: Active, not recruiting Phase 3 Location: North Carolina, Mississippi, New York, California
  • Cytarabine in Treating Young Patients With Recurrent or Refractory Ewing's Sarcoma
    RATIONALE: Drugs used in chemotherapy, such as cytarabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. PURPOSE: This phase II trial is studying how well cytarabine works in treating young patients with recurrent or refractory Ewing's sarcoma.
    Status: Completed Phase 2 Location: North Carolina, Massachusetts, Texas, New Mexico
  • Chemotherapy in Treating Patients With Metastatic Ewing's Sarcoma or Primitive Neuroectodermal Tumor
    RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating patients who have metastatic Ewing's sarcoma or primitive neuroectodermal tumor.
    Status: Active, not recruiting Phase 2 Location: England

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    There are three study types available to search on:

    • Interventional studies test specific treatments, procedures, devices, or behavioral changes.
    • Observational studies do NOT test for specific treatments or other changes. These studies measure health outcomes are studied in a specific group of individuals.
    • Expanded Access Records are not studies, they describe experimental treatments for patients who are not eligible to participate in clinical trials and are not responding to regular treatments. All experimental treatment use outside of clinical trials is documented in these records. Participants must be recommended by their provider to be eligible for expanded access to experimental treatment.
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    • Most clinical trials are designated as phase I, II, III, or IV (based on the FDA Regulations):
    • Phase I - Researchers test a new drug or treatment for the first in a small group of people (20-80) to evaluate its safety, determine a safe dosage range, and identify side effects.
    • Phase II - The study drug or treatment is given to a larger group of people (100-300) to determine if it is effective and to further evaluate its safety.
    • Phase III - The study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
    • Phase IV - The study drug or treatment is monitored after approval by the FDA to learn additional information including the drug's risks, benefits, and optimal use.
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    Outcome measures are used to evaluate trial results. For example, an obesity treatment might be evaluated by a measure of weight loss after 6 months. Measures can also be used to track side effects, such as number of heart attacks or mortality rate.

    (examples: response to drug or reduced mortality)
  • (examples: NIH or Merck)
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