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Retinoblastoma is a childhood cancer which affects the retina of the eye. The retina is the
light sensitive layer of tissue that lines the back of the eyeball; sends visual messages
through the optic nerve to the brain. When only one eye is affected, this is known as
unilateral retinoblastoma and when both eyes are affected, it is called bilateral
retinoblastoma. Treatme...
Status: Recruiting
Phase 3
Location: Tennessee
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The purpose of this study is to explore whether the drug pegylated-interferon-alfa-2b
(PEG-IFN) has any effect on a certain type of immune cell (called natural killer cells) in
patients with eye melanoma.
Status: Recruiting
Location: Georgia
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This study will evaluate whether therapy that suppresses the immune system given to treat
inflammatory diseases of the eye is associated with a greater risk of death and of cancer.
Inflammatory diseases of the eye, including uveitis, scleritis, and mucous membrane
pemphigoid, are major blinding diseases. For some patients, treatment with corticosteroids is
not enough to ...
Status: Completed
Location: Maryland, Oregon, Massachusetts
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The purpose of this study is to test the safety and effectiveness of Avastin introduced into
the inside of the eyeball in causing shrinkage of the uveal melanoma (tumor of the eye).
Avastin is an anti-cancer drug specially designed to shrink blood vessels within tumors.
Status: Completed
Location: New York
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Retinoblastoma is a cancer of the eye that occurs exclusively in children. The treatment for
retinoblastoma may include surgery, chemotherapy, radiation and local treatments to the eye
such as freezing (cryotherapy) and local radiation (brachytherapy). In some cases, a child
with retinoblastoma will have active cancer in a single remaining eye with useful vision. In
such...
Status: Not yet recruiting
Phase 1/Phase 2
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RATIONALE: Cyclosporine eye drops may prevent graft-versus-host disease of the eye in
patients who have undergone donor stem cell transplant for hematologic cancer or bone marrow
failure disorder.
PURPOSE: This randomized phase I trial is studying how well cyclosporine eye drops work in
preventing graft-versus-host disease of the eye in patients who have undergone donor...
Status: Recruiting
Phase 1
Location: Tennessee
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RATIONALE: Genetic studies may help in understanding the genetic processes involved in the
development of some types of cancer and may lead to both earlier detection and prevention of
tumors.
PURPOSE: Clinical trial to study the genetic and clinical features of patients who have
xeroderma pigmentosum, Cockayne syndrome, the xeroderma pigmentosum/Cockayne syndrome
...
Status: Recruiting
Location: Maryland
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Over the past 15 years, intravenous chemotherapy has become the most popular conservative
(eye-saving) method for retinoblastoma treatment because it is often effective and usually
safe. In recent years, there has been much interest in providing highly focused (focal)
chemotherapy to a diseased organ including the liver, brain, and eye. With focused
chemotherapy, the che...
Status: Recruiting
Location: Pennsylvania
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The purpose of this study is to determine whether an Internet-based program, Sleep Healthy
Using the Internet (SHUTi, or "Shut-Eye"), can help to improve the sleep of people who are in
remission from cancer and experiencing symptoms of insomnia.
Status: Active, not recruiting
Location: Virginia
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This study will determine if an experimental drug called sunitinib malate (Sutent) can help
slow or stop the growth of eye angiomas (abnormal growth of blood vessels) in people with Von
Hippel-Lindau (VHL) syndrome. VHL is a genetic disorder that increases production of body
chemicals called vascular endothelial growth factor (VEGF) and platelet derived growth factor
(PD...
Status: Recruiting
Phase 1/Phase 2
Location: Maryland