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Aug 12, 10 06:07AMSome of the most common and disabling consequences of brain injury are deficits in cognition, such as difficulty with sustained attention, memory, organization, and goal management. The long-term goal of this research program is to develop and test novel neuroscience-based cognitive assessment tools and interventions for improving attentional regulation and related "exec...Location: VA Northern California HCS Status: Not yet recruiting» Read more
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Aug 12, 10 06:41AMThe complexity of sensorimotor control required for hand function as well as the wide range of recovery of manipulative abilities makes rehabilitation of the hand most challenging. The investigators past work has shown that training in a virtual environment (VE) using repetitive, adaptive algorithms has the potential to be an effective rehabilitation medium to facilitate...Location: New Jersey Institute of Technology Status: Recruiting» Read more
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Aug 12, 10 08:21AMThe investigators hypothesize that cognitive remediation will be superior to the active control group on the change from baseline to study end point of cognitive remediation phase on both co-primary outcome measures (standardized composite MATRICS score and Cognitive Assessment Interview).Location: Northwestern University Status: Not yet recruiting» Read more
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Aug 12, 10 08:59AMThis study is designed to document the loss of sociomoral emotions (like empathy, guilt, and embarrassment) in patients with behavioral variant frontotemporal dementia. The loss of these emotions, which function as the motivators for social behavior, will manifest in specific interpersonal behaviors. These behaviors will correlate with regional changes in regional change...Location: UCLA Department of Neurology Status: Recruiting» Read more
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Aug 12, 10 11:09AMConstraint-Induced Movement therapy, also known as CI therapy, is an approach to physical rehabilitation derived from basic behavioral and neuroscience research. It has been shown to be efficacious for rehabilitating use of the more-affected arm in individuals more than one year after stroke with mild to moderate motor impairment. The first component of the therapy is in...Location: University of Alabama at Birmingham Status: Recruiting» Read more
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Sep 03, 10 09:10AMBackground: - Previous research has shown that certain parts of the brain are involved in voluntarily stopping an ongoing motor response (movement); however, it is not known whether this same network is also involved in suppressing an urge to act. Traumatic brain injury (TBI) can significantly impair the brain's ability to voluntarily stop or inhibit certain actions. ...Location: National Institutes of Health Clinical Center, ... Status: Recruiting» Read more
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Feb 01, 11 07:10AM1. Apolipoprotein E gene (ApoE) is the most important genetic factor for Alzheimer disease (AD) and an important genetic factor for outcome of brain injury situations. 2. Function magnetic resonance imaging (fMRI) is a powerful tool for study of both brain regional functions and brain network. 3. Study about genetic contribution on fMRI is an emerging con...Location: Chaur-Jong Hu Status: Recruiting» Read more
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Sep 14, 11 07:10AMDespite the clear importance of adolescence in the emergence of a number of disease states and processes, there is surprisingly little known about how the endocrine and metabolic events accompanying puberty in humans impact normal developmental neurobiology. Epidemiologic studies have identified sexual dimorphisms in the prevalence of several neuropsychiatric disorders, ...Location: National Institutes of Health Clinical Center, ... Status: Recruiting» Read more
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Dec 16, 11 06:00AMBackground: - Different regions of the brain are activated when a person performs a task. Electroencephalograms (EEGs) and near-infrared spectroscopy (NIRS) are tests that detect changes in the brain. EEG looks at changes in electrical signals, and NIRS looks at changes in blood flow. These tests can detect local changes in brain activity in a safe and noninvasive...Location: National Institutes of Health Clinical Center, ... Status: Recruiting» Read more
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Mar 16, 12 08:00AMWe hypothesize that newly developped NIRS sensor (EQUANOX Advance™, 8004CA, NONIN Medical, USA)is able to detect ischemic events recorded by brain tissue oxygen probe (Licox, Integra Neurosciences, USA) and that values are correlated.Location: Sainte Anne Military Teaching Hospital Status: Completed» Read more
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