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To validate a new Alzheimer's Disease scale against other rating tools in subjects with
dementia of Alzheimer's type, treated with memantine.
Location: University Clinic Gustav Carus
Status: Completed
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Neuropsychiatric symptoms form part of the clinical picture of Alzheimer's disease (AD) and
other dementias. Irrespective of the severity of the disease, the most frequently
encountered symptom is apathy. Apathy is increasingly diagnosed in patients with
neurological and psychiatric conditions. Apathy is a disorder of motivation, defined as "the
direction, intensity and ...
Location: Nice University Hospital
Status: Not yet recruiting
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Lithium salts have been used for the treatment of psychiatric disorders for over five
decades, mostly as a mood-stabilizing drug. Recent evidence points to the inhibition of the
enzyme glycogen synthase kinase-3beta (GSK3) as one of its mechanisms of action. The
overactivity of this enzyme has been implicated in the pathogenesis of Alzheimer's disease
(AD), given its inv...
Location: Institute of Psychiatry, Faculty of Medicine - ...
Status: Active, not recruiting
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The current study is intended to enrich and extend the database of Alzheimer's Disease (AD)
and healthy control (HC) MEG scans and will include patients meeting DSM-IV-TR criteria for
dementia of Alzheimer's type, and age- and gender-matched HC subjects meeting criteria of
normal neurological function. This study will include 2 MEG and electroencephalography (EEG)
scans ...
Location: Rush Alzheimer's Disease Center
Status: Completed
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This study measures whether the symptoms of frontotemporal dementia (FTD) can be
successfully treated by (a) biofeedback training to increase brain blood flow, (b)
biofeedback to increase the frequency of the brain's dominant brainwave rhythm, and (c)
rhythmic stimulation to increase the brain's dominant brainwave frequency.
Location: Quietmind Foundation
Status: Completed
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This study is designed to document the loss of sociomoral emotions (like empathy, guilt, and
embarrassment) in patients with behavioral variant frontotemporal dementia. The loss of
these emotions, which function as the motivators for social behavior, will manifest in
specific interpersonal behaviors. These behaviors will correlate with regional changes in
regional change...
Location: UCLA Department of Neurology
Status: Recruiting
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The purpose of this 16-week research study is to determine whether a drug called memantine
hydrochloride (memantine) has the potential to help improve memory and other cognitive
abilities of young adults with Down syndrome. Memantine (Namenda®) is a drug approved by the
Food and Drug Administration (FDA) for patients with moderate to severe Alzheimer-type
dementia. About...
Location: The Children's Hospital
Status: Recruiting
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The present study aims at combining biochemical methods with various types of imaging
techniques to identify the pathophysiology of Alzheimer's disease (AD). Our main interest is
to find markers associated with the very early steps in the pathology of this disease. We
shall thus screen for i) molecules in cerebrospinal fluid (CSF) and plasma specific for AD,
and ii) brai...
Location: Unit of Cognitive Medicin, Skåne University Hos...
Status: Recruiting
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The effectiveness of reminiscence for dementia has been claimed as an effective tool, but
scientific validation and systematic assessment of this method is needed. Materials and
Methods: A randomized controlled trial (RCT) was conducted to search whether a reminiscence
program is associated with improvement of quality of life of demented long term care
residents. The tri...
Location: Faculty of Psychology
Status: Completed
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The primary aim of the DEDEMAS (Determinants of Dementia After Stroke) study is to identify
predictors of post stroke depression (PSD). A particular focus will be on biological markers
(neuroimaging, biochemical markers derived from blood) and on interactions between vascular
and neurodegenerative mechanisms. For this purpose patients with an acute stroke and without
pri...
Location: Interdisciplinary Stroke Center Munich, Kliniku...
Status: Not yet recruiting
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