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The purpose of this research is to determine if a film to prevent adhesions will improve the
area of distribution of a contrast dye (representative of chemotherapy) in the abdominal
cavity (belly) of women who have undergone surgery for ovarian cancer as compared with
patients who have not had adhesion barrier sheets placed in the belly. It is believed that
this film, S...
Location: Vancouver General Hospital
Status: Not yet recruiting
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In a phase II open-label study women with recurrent epithelial ovarian cancer, fallopian
tube cancer, or primary peritoneal carcinoma will be treated with bevacizumab 15 mg/kg and
irinotecan 250mg/m2 every 3 weeks.
Location: New York University Clinical Cancer Center
Status: Not yet recruiting
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The purpose of this study is to determine the safety and efficacy of an investigational
vaccine in ovarian cancer patients in remission and to determine its ability to prevent
cancer from returning.
Location: California Cancer Care, Inc.
Status: Recruiting
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A supra-additive cytotoxic effect was seen when CAI and paclitaxel were given to human
ovarian cancer cells sequentially in tissue culture. We have demonstrated that CAI given
for 8 days followed by paclitaxel is reasonably well tolerated and that paclitaxel
administration causes a dose-dependent increase in CAI plasma concentration. CAI is a
cytostatic drug and contin...
Location: National Institutes of Health Clinical Center, ...
Status: Completed
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RATIONAL FOR STUDYING IV NAC AS POTENTIAL CHEMOPROTECTANT:
Cisplatin has shown efficacy in the treatment of subjects with epithelial ovarian cancer.
Systemic toxicities associated with cisplatin include nephro, oto, and nerve toxicities. It
may be possible to reduce the toxicities of cisplatin by administering it in conjunction
with IV NAC. NAC may reduce cisplatin rel...
Location: Oregon Health & Science University
Status: Recruiting
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The best way to treat MBO in patients with ovarian cancer has not been studied enough by
trials that assess how more than one treatment arm (surgical, chemotherapeutic, supportive
care approaches) affects clinical outcomes like resolution of bowel obstruction, survival,
and quality of life. To improve patient outcomes, we must assess which patients will do
better with p...
Location: Princess Margaret Hospital
Status: Recruiting
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The purpose of this study is to determine if patients with p53 mutated epithelial ovarian
cancer that have been treated with first line treatment (paclitaxel - carboplatin
combination therapy) and that have shown early relapse (within 3 months) or progression
during treatment will benefit from treatment with Wee-1 inhibitor MK-1775 and carboplatin.
Location: Netherlands Cancer Institute - Antoni van Leeuw...
Status: Recruiting
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This is a Phase II study to determine the feasibility of administering neoadjuvant
carboplatin, paclitaxel, and bevacizumab without excessive dose modification or cycle delay
in patients with epithelial ovarian cancer, primary peritoneal cancer or fallopian tube
cancer.
Location: Columbia University Medical Center
Status: Recruiting
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The purpose of this study is to create new tests to identify biomarkers for ovarian cancer
so that a screening test can be developed. For patients who have a diagnosis of ovarian
Cancer, researchers will use blood samples before and after treatment to see if disease
status can be determined by measuring the amount of biomarker.
Location: University of Virginia
Status: Not yet recruiting
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Intend of use: A blood test for Cancer Associated Antibodies (CAAA) is an aid in initial
diagnosis of ovarian cancer in women with suspected ovarian pathology as detected by primary
diagnostic techniques.
Test Description: Blood is collected from patients and serum/plasma is tested for the
presence of CAAA on experimental test kit.
Objectives: To assess the effec...
Location: Eventus Diagnostics
Status: Not yet recruiting
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