-
Aug 23, 10 04:41AMMucociliary clearance, in which mucus secretions are cleared from the breathing airways, is the primary defense mechanism for the lungs. Inhaled particles, including microbes that can cause infections, are normally entrapped in mucus on the airway surfaces and then cleared out by the coordinated action of tiny hair-like structures called cilia. Individuals with primary c...Location: The Hospital for Sick Children Status: Active, not recruiting» Read more
-
Aug 23, 10 12:44PMHealthy volunteers and patients with diseases that involve problems clearing mucus from the lungs will be examined and tested to better understand the reasons for recurring lung infections in these patients and to try to develop better ways to diagnose and treat them. The study will also try to identify the genes responsible for these diseases. Healthy volunteers 18 yea...Location: National Institutes of Health Clinical Center, ... Status: Recruiting» Read more
-
Aug 23, 10 01:48PMOBJECTIVES: I. Characterize the clinical presentation of patients with primary ciliary dyskinesia. II. Identify the genetic mutations associated with this disease.Location: University of North Carolina School of Medicine Status: Completed» Read more
-
Aug 23, 10 03:33PMThis study will examine genetic material obtained from blood and tissue samples of patients with congenital heart disease (CHD) and heterotaxy (an abnormality in the left-right positioning of organs in the body, also called situs inversus) to gain a better understanding of these disorders and of a lung disease called primary ciliary dyskinesia (PCD). CHD is prevalent in ...Location: Childrens National Medical Center Status: Recruiting» Read more
-
Aug 23, 10 06:46PMMucociliary clearance, in which mucus secretions are cleared from the breathing airways, is the primary defense mechanism for the lungs. Inhaled particles, including microbes that can cause infections, are normally entrapped in mucus on the airway surfaces and then cleared out by the coordinated action of tiny hair-like structures called cilia. Individuals with primary c...Location: Stanford University Status: Recruiting» Read more
-
Aug 12, 10 01:06AMThe objective of this study is to compare the lower airways inflammatory response to infection/pulmonary exacerbation among children known to have Primary Ciliary Dyskinesia (PCD) with children known to have Cystic Fibrosis (CF) as measured by the presence of inflammatory mediators in expectorated/induced sputum.Location: The Hospital for Sick Children Status: Recruiting» Read more
-
Aug 12, 10 02:23AMThe fraction of exhaled nitric oxide (FeNO) in expired air is a reliable measure of airway inflammation and has been used as a marker in asthma and other respiratory illnesses such as primary ciliary dyskinesia, bronchopulmonary dysplasia (BPD), liver cirrhosis, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF). Although, some exquisite bench research ex...Location: Winthrop University Hospital Status: Recruiting» Read more
-
Aug 12, 10 05:54AMExercise induced bronchospasm (EIB), also known as exercise induced asthma (EIA) is a transient obstruction to airflow triggered by exertion. It is now a well known identity, center of discussion in recent years, particularly in the athletes' world. It is more common in asthmatic individuals (regardless of severity of disease), but it is also seen in otherwise healthy s...Location: Winthrop University Hospital Status: Not yet recruiting» Read more
-
Aug 12, 10 07:54AMBackground: in various pediatric pulmonary diseases such as asthma, cystic fibrosis or bronchopulmonary dysplasia an increased inflammation is present. Measuring this inflammation is often hardly possible and requires invasive techniques such as bronchoscopy. With the use of exhaled breath condensate (EBC) or exhaled breath (EB) analysis it is possible to measure the in...Location: Maastricht University Medical Centre, Pediatric... Status: Recruiting» Read more
-
Nov 23, 10 05:00AMThe purpose of this study is to determine whether patients with primary ciliary dyskinesia (PCD) have reduced or absent otolith function.The otolith system is a specific part of the inner ear vestibular (balance) system that detects linear movement.Location: Charing Cross Hospital Status: Not yet recruiting» Read more
Primary Ciliary Dyskinesia
Primary Ciliary Dyskinesia (PCD) is a term for inherited disorders of the structure and/or function of cilia. The disorders include PCD with situs inversus (also known as Kartagener syndrome), PCD without situs inversus and ciliary aplasia. It has also been called immotile cilia syndrome.
People with PCD do not have functioning cilia. Their cilia may be completely paralyzed (immotile cilia), beat inadequately or in an ineffective fashion (dyskinetic cilia), or may not have developed at all (ciliary aplasia). Without functioning cilia, people with PCD are unable to protect their respiratory system. Frequent infections of the lungs, ears, throat, and sinuses are common.
Clinical Trials
New Clinical Trials for Primary Ciliary Dyskinesia. See all or search for more Clinical Trials.
Join to have conversations with knowledgeable people and get real-time updates
Question Guidelines
- Anything you write on Medpedia Answers is publicly viewable and searchable.
- Questions should be a request for information only — not a request for direct medical advice, a diagnosis, or a treatment plan.
Examples:
- Is a sore throat a symptom of swine flu?
- What are the benefits and drawbacks of a tonsillectomy?
You must be a member of this Community to do that.
Join this Community to:
- Ask a question
- Start or join a discussion
- Get real-time email updates
You must be a member of this Community to do that.
Join this Community to:
- Ask a Question
- Start or Join a Discussion
- Get real-time email updates
Join this Community to:
- Ask a question
- Start or join a discussion
- Get real-time email updates
Join this Community to:
- Ask a question
- Start or join a discussion
- Get real-time email updates