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Aug 24, 10 03:27AMRATIONALE: Drugs used in chemotherapy, such as oxaliplatin and fluorouracil, work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Oxaliplatin and fluorouracil may make tumor cells more sensitive to radiation therapy and may kill more tumor cells. Giving chemotherapy and radi...Location: Hulston Cancer Center at Cox Medical Center South Status: Active, not recruiting» Read more
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Aug 23, 10 02:37AMRATIONALE: Patients with xeroderma pigmentosum are more likely to develop skin lesions in sun-affected areas. These skin lesions, such as actinic keratoses, can develop into skin cancer. T4N5 liposome lotion may reduce actinic keratoses or other sun-induced skin damage in patients with xeroderma pigmentosum. PURPOSE: Randomized double-blinded phase III trial to compare ...Location: University of Michigan Comprehensive Cancer Center Status: Active, not recruiting» Read more
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Aug 23, 10 02:53AMRATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Isotretinoin may be effective in preventing the development or recurrence of skin cancer. PURPOSE: Clinical trial to study the effectiveness of isotretinoin in preventing or slowing the growth of skin cancer in patients who have xeroderma pigmentosum...Location: Intramural Research Program Status: Completed» Read more
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Aug 23, 10 05:35AMRATIONALE: Screening individuals who have a xeroderma pigmentosum gene alteration may help doctors identify persons at risk of developing cancer and identify other cancer genes. PURPOSE: This clinical trial is comparing cancer risk in individuals who have a xeroderma pigmentosum gene alteration to those who don't.Location: Warren Grant Magnuson Clinical Center - NCI Cli... Status: Recruiting» Read more
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Aug 23, 10 06:14AMPrimary: to investigate the effects of DNA repair gene polymorphisms on prostate cancer susceptibility, pathological grade, disease stage and clinical outcome Secondary: to understand the association between DNA repair gene polymorphism and prostate cancer and provided important information for screening, prevention and treatment of prostate cancerLocation: National Taiwan University Hospital Status: Recruiting» Read more
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Aug 23, 10 08:47AMStudy aim: To determine the effect of an intensified daily photoprotection over 24 months with an SPF30 sunscreen and an after sun-lotion both containing liposomal DNA repair enzymes in a population of patients at high-risk for skin cancer, including xeroderma pigmentosum (XP) and basal cell nevus syndrome.Location: Medical University of Graz, Department of Derma... Status: Completed» Read more
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Aug 23, 10 10:30AMThe studied materials contains surgically specimens of two groups of patiens with non-small cell lung cancer who have received two regimens of induction (neoadjuvant) chemotherapy before tumor resection. Pathological specimens of pre-chemotherapy and post-chemotherapy whatever retrievable will be collected. The protein ad RNA expression of DNA repair genes (ERCC1, ERCC2,...Location: National Taiwan University Hospital Status: Recruiting» Read more
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Aug 23, 10 12:02PMRATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer and may lead to both earlier detection and prevention of tumors. PURPOSE: Clinical trial to study the genetic and clinical features of patients who have xeroderma pigmentosum, Cockayne syndrome, the xeroderma pigmentosum/Cockayne syndrome ...Location: Warren Grant Magnuson Clinical Center - NCI Cli... Status: Recruiting» Read more
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Aug 12, 10 11:03AMXeroderma Pigmentosum (XP) is a rare skin condition that causes extreme sensitivity to the sun and an increased incidence of skin cancers. The purpose of this study is to find out more about XP patient experiences and their quality of life.Location: Henry Ford Medical Center, New Center One Status: Recruiting» Read more
Xeroderma Pigmentosum
Hereditary disease, transmitted with recessive autosomal modality, the XP is characterized from extreme photosensivity that causes strict and premature damages to level of the cutis and of the eyes. Its incidence is of 1:250000 in Europe and USA, while in Japan the relationship is of 1:40000. In the child affected by XP also short exposure to the sun's ultraviolet rays determines severe cutaneous sunburn with slow resolution, therefore it is from avoiding sources of ultraviolet cancellations categorically, considering moreover that the effects of the exposures are cumulative in the time.
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