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The purpose of this study is to gain a better understanding of alkaptonuria and collect
medical data on patients who may later participate in new drug trials for this rare genetic
disease. In alkaptonuria, a pigment called homogentisic acid collects in bone and
connective tissue, causing arthritis and eventually bone fractures, and also causes
discoloration in the ears ...
Location: National Institutes of Health Clinical Center, ...
Status: Recruiting
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This study will investigate the underlying cause of Chediak-Higashi syndrome (CHS)-a rare
inherited disease-and define the full spectrum of medical complications associated with it.
It will study the LYST gene - the gene responsible for classic CHS-and investigate other
genes that may cause milder forms of the syndrome.
Patients with CHS have a range of medical problems...
Location: National Institutes of Health Clinical Center, ...
Status: Recruiting
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This study provides training opportunities for critical care specialists in evaluating and
treating critically ill patients. Patients enrolled in the study receive standard tests and
treatments. The study objectives are to:
- Provide additional training for staff of the NIH Clinical Center intensive care unit,
including physicians, nurses, fellows, and other tra...
Location: National Institutes of Health Clinical Center, ...
Status: Completed
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The goals of the trial are:
- To determine the prevalence of osteoporosis in subgroups of COPD patients.
- To look for risk factors of osteoporosis in COPD patients.
- To create sub-groups for prospective research concerning the effects of bisphosphonates
on osteoporosis variables in COPD patients.
Location: Catharina Hospital Eindhoven
Status: Completed
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The primary objective of this research is to pilot test a brief mental heath treatment
specifically tailored to meet the needs of chronically ill patients with anxiety and/or
depression. Using an open-trial format, the proposed study will examine the feasibility of a
brief psychosocial intervention. Primary outcomes will assess intervention effects on
patient and clinici...
Location: Houston VA Medical Center
Status: Completed
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This is a study to evaluate the effects of early pulmonary rehabilitation within 10 days
after discharge from the hospital after a COPD exacerbation on exercise tolerance,
exacerbations, re-admissions and the quality of life during 6 months.
Location: Isala Klinieken
Status: Terminated
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The purpose of this study is to determine the impact of erythropoietin treatment of anemia
on exercise capacity of patients with chronic obstructive pulmonary disease (COPD).
Location: CHU Henri Mondor
Status: Suspended
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Patients who are admitted to the outpatient pulmonology department by a general practitioner
or specialist with a chest X-ray suspicious for lung cancer with an age between 18 and 80
years are suitable for participation. The X-ray and referral are studied by a chest
physician (by phone or fax ). Selected patients are invited to enter the study after
answering a questionn...
Location: Isala Klinieken
Status: Recruiting
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The purpose of this study is to evaluate the effects of an integrated multidisciplinary
rehabilitation program on health related quality of life in the 12 months postoperative
period in patients with an elective thoracotomy and to evaluate the effects of the program
on general quality of life (SF-36), acute/chronic post-thoracotomy pain, impairment (changes
in pulmonary ...
Location: Isala Klinieken
Status: Recruiting
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Background:
- Idiopathic CD4+ lymphocytopenia (ICL) is a condition in which there is a decreased
level of CD4+ lymphocytes (a type of white blood cell), which can lead to opportunistic
infections or autoimmune disorders and diseases.
Objectives:
- To characterize the natural history with regard to CD4+ T cell count and onset of
infecti...
Location: National Institutes of Health Clinical Center, ...
Status: Recruiting
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