Today I’ll be live-blogging the Bay Area Aging Meeting being held at Stanford.
Each session will have its own article; this entry will serve as a central hub for all related entries – the links below will go live as soon as the sessions start.
The organizers have encouraged me to blog the talks, as I did last year. More importantly, we’re hoping that the conference attendees (and others following along elsewhere in the world) will chime in via the internet.
There are two main ways to play along: in the comments below each session entry, and via Twitter.
If you’re tweeting during the talks, mark your tweets with the hashtag #baam10. (Even if you’re not tweeting, you can use the hashtag to follow the tweetstream here.) If you have no idea what I’m talking about, don’t worry about it. Follow along as the blog entries emerge, or just sit back and enjoy the conference.
Comments
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Sign in nowIlya B Says:
October 18, 2010 at 5:00 pm
@Dakine Being more specific won’t hurt. No such effects as far as I googled it up. Pls. elaborate.
Ilya,
You are the one who made claims inconsistent with beta-blocker and metformin pharmacolgy profiles. Google “pharmacology of beta-blockers” or online “Physician’s Desk Reference” (PDR), or “rxlist.com”, etc., etc., etc.
I look forward to your acknowledgement of lesson learned–to check YOUR facts before spewing ignorant bluster, let alone expecting others to do that work for you.
–Dakine
@Dakine Just google “metformin side effects” , check also Wikipedia and kindly STFU. No more comments. “Don’t argue with imbeciles”- Lesson learned.
@Dakine And to finish you off here is the study that plainly shows who is ignorant:
http://jpet.aspetjournals.org/content/310/2/614.full.pdf+html
With which I rest my case.
@Dakine Oooops, I deeply apologize as you referred to my wrong classification of Metformin as a beta blocker, not biguanide and ascribing Metformin properties of a beta blocker. I’m sorry about that it was long time ago and erred there.
I hope we have a great conference.
What is Edu? Is it a marker for new DNA synthesis?
Very interesting talk! Aging talks never get old.
Looks like it:
EdU, a new thymidine analogue for labelling proliferating cells in the nervous system
“Unlike the commonly used BrdU, EdU detection requires no heat or acid treatment. …”
I wonder whether there is asymmetric DNA segregation in yeast or asymmetric divisions in flies or worms.
What is the mechanism? How can a dividing grandaughter cell know which DNA is new? Are there methylation marks?
Has no one ever looked at yeast asymmetrical division? We know about the cell content asymmetry between mothers and daughters; I would be surprised if no one had looked at DNA.
(Maybe the last talk will answer the question
)
@Matthew McGee
Very, very cool talk. I’d like to know what the pathology of longevity mutants (eg daf-2) looks like.
Also relevant to this is work done in our lab by Xia Liu, see his paper:
Analysis of cell fate from single-cell gene expression profiles in C. elegans.
Liu X et al., Cell. 2009
What do we think is happening to the nuclei? It’s one thing for a nucleus to shrink, another thing altogether for it to disappear.
Matt’s speculation about the fate of the nuclei:
You can still see the lamin B, but no DAPI. This suggests that the DNA is being degraded, but the compartment remains intact.
Chris, you have an amazing talent for live blogging at research conferences!!!
Thanks Victoria! Great talk today, by the way.
@David Furman
I would be interested in knowing whether you can match your expression profile to that of a known small molecule. That would provide a way of pharmaceutical intervention for (elderly) poor responder subjects.
You can do this using the Connectivity Map (http://www.broadinstitute.org/cmap/) (Lamb et al., 2006 Science).
Free radicals cause cell damage and cell death, this is clear, the problem is antioxidants do not seem to extend life span.
It is time to consider the possibility that the senescence of intracellular constituants is regulated as a standard adaptive trait subject to standard Darwinian selection processes.
Here is a theory that proposes such a mechanism.
http://sites.google.com/site/limitsofgrowththeoryofaging/
@ouroboros: great site! so pumped to interact with fellow meeting-goers on this slick blog. also, great commentary on the talks–i’m impressed by your approachable summaries of scientific babble…keep up the good work!
@Stuart: awesome questions–budding yeast seem to segregate chromosomes randomly: see “Random Segregation of Chromatids at Mitosis in Saccharomyces cerevisiae” from Daniel Burke’s lab. the list of evidence for/against existence of asymmetric DNA segregation in various organisms is too extensive to list, but tom rando has a couple of reviews on the topic. as for mechanism, your guess is as good as mine, but it’s something we want to sort out.
@Greg Charville
Have you followed the asymmetric segregants beyond one division? Do they eventually lose the gamma-H2AX or is it always there?
Also, I am bit confused about the classfication of these cells: are the cells displaying the DNA damage response only satellite cells or are they a mix of satellite cells, myoblasts, and their intermediates?
Thanks for the blogging. Very clear writing.
Now bring on the whale genes.
Of course you can fit it into evolution! It just so happened that when the first multicellular organisms mutated to be the first sexually reproducing species of the animal kingdom then DNA gave way to the design of immortal life. (sarcasm)
[...] Melanie recently summarized some important themes in aging research that were discussed at the second Bay Area Aging Meeting: [...]
[...] IEET [and] recently summarized some important themes in aging research that were discussed at the second Bay Area Aging Meeting. … Two interesting talks concerned UCP2 (mitochondrial uncoupling protein 2) an enzyme which [...]
[...] Bay Area Aging Meeting: Session I Cognitive decline occurs with age: speed of processing, working memory, and long-term memory all decline. Presumably cell loss is partially to blame – not only loss of neurons, but also other types of cells (e.g., oligodendrocytes). Neural stem cells (NSC) can regenerate lost cells to some extent, but their ability to do so diminishes with age. [...]
[...] Bay Area Aging Meeting: Session IV If aging is an engineering problem, then we should be able to solve the engineering challenges more easily in simple systems. By introducing genes from a long-lived organism into the genome of a short-lived organism, it should be possible to add pro-longevity functions – in effect “upgrading” the short-lived animal so that it lives longer. Sagi has set out to do just that, by transferring genes from the long-lived zebrafish (4-year lifespan) to the short-lived worm (4-week lifespan). [...]
Valerie.. you may have celiac, which could inhibit Igf-1 production. Celiac can cause malnutrition.. also.. diabetes & celiac seem to have some cooerlation??? It is possible you are GH resistant, therefore GH therapy will do you no good. Direct Igf-1 therapy could do the trick, however a gluten free diet could be the cure!! Good luck! I hope you get feeling better soon.
We are presently going through all this with my son. Lisa M
hi there
i like the website as i am interested in the science and use to be a research agronomist.
i found the following interesting an on topic
Mannoheptulose: glycolytic inhibitor and novel caloric restriction mimetic George Roth1, Mike Hayek2, Stefan Massimino2, Gary Davenport2, Robert Arking3, Andrzej Bartke4, Michael Bonkowski4 and Don Ingram5
Caloric restriction (CR) is the most robust and reproducible strategy for retarding aging. Benefits of CR have been demonstrated in multiple species, but application to human or companion animal aging represents a challenge. In 1998 the concept of CR “mimetic” (CRM) was introduced as a method to obtain “anti-aging” and health-promoting benefits of CR without reducing food intake. We hypothesized that an effective CRM would best mimic the effects of CR if it impeded initial stages of energy metabolism. We focused initially on glycolytic inhibition using 2-deoxyglucose (2DG). Upon entry into cells, this glucose analog is phosphorylated and becomes a strong competitive inhibitor of phosphohexose isomerase. 2DG effectively induces a CR-like state in rats based on metabolic effects such as reduced plasma glucose, insulin, body temperature, pulse, heart rate and inhibiting tumor growth. Results show 2DG has a narrow window between efficacy and toxicity so recently we shifted our focus to mannoheptulose (MH), a seven-carbon sugar that reduces glycolysis via hexokinase inhibition. MH appears non-toxic with negligible effects on food intake and BW, and increased insulin tolerance by 25% in mice. MH extends median and maximal lifespan (~15%) in D. melanogaster and median lifespan (~30%) in C3H/HeJ mice. These findings, coupled with simple extraction from avocados, suggest that MH may be a practical, highly effective CRM.
the amount of avocado which needs to be taken as far as i can calculate is about one large avocado a day
here is the abstract of the mannoheptulose paper,I could not find a copy of the complete paper. a 30% increase in longevity of mice is not a bad first go
http://www.fasebj.org/cgi/content/meeting_abstract/23/1_MeetingAbstracts/553.1
i posted this elsewhere on the site but this might be the right place
hi there
i like the website as i am interested in the science and use to be a research agronomist.
i found the following interesting an on topic
Mannoheptulose: glycolytic inhibitor and novel caloric restriction mimetic George Roth1, Mike Hayek2, Stefan Massimino2, Gary Davenport2, Robert Arking3, Andrzej Bartke4, Michael Bonkowski4 and Don Ingram5
Caloric restriction (CR) is the most robust and reproducible strategy for retarding aging. Benefits of CR have been demonstrated in multiple species, but application to human or companion animal aging represents a challenge. In 1998 the concept of CR “mimetic” (CRM) was introduced as a method to obtain “anti-aging” and health-promoting benefits of CR without reducing food intake. We hypothesized that an effective CRM would best mimic the effects of CR if it impeded initial stages of energy metabolism. We focused initially on glycolytic inhibition using 2-deoxyglucose (2DG). Upon entry into cells, this glucose analog is phosphorylated and becomes a strong competitive inhibitor of phosphohexose isomerase. 2DG effectively induces a CR-like state in rats based on metabolic effects such as reduced plasma glucose, insulin, body temperature, pulse, heart rate and inhibiting tumor growth. Results show 2DG has a narrow window between efficacy and toxicity so recently we shifted our focus to mannoheptulose (MH), a seven-carbon sugar that reduces glycolysis via hexokinase inhibition. MH appears non-toxic with negligible effects on food intake and BW, and increased insulin tolerance by 25% in mice. MH extends median and maximal lifespan (~15%) in D. melanogaster and median lifespan (~30%) in C3H/HeJ mice. These findings, coupled with simple extraction from avocados, suggest that MH may be a practical, highly effective CRM.
for abstract
http://www.fasebj.org/cgi/content/meeting_abstract/23/1_MeetingAbstracts/553.1
the amount of avocado which needs to be taken as far as i can calculate is about one large avocado a day
This post is great. thank you for sharing these helpful infos. I appreciate your work man
[...] seems that SENS theorist Aubrey de Grey, who is chronologically 45, (BioBarCamp photo by Ricardo) is taking roughly the above position in a recent interview. Aubrey [...]
Howdy! This post could not be written any better! Reading through this post reminds me of my old room mate! He always kept talking about this. I will forward this article to him. Pretty sure he will have a good read. Many thanks for sharing!
Does anyone know of a distributor of this compound for research?
I’d like to know that myself. More on the chemical structure is available in Wikipedia’s plastoquinone article (SkQ1 is plastoquinonyl-decyl-triphenylphosphonium). I can’t find a commercial source. Skulachev and co-workers may be making it themselves.
Hello Dr.
I am film producer interested in your research. I would like to interview you at your leisure to learn if your story will bring a favorable and compelling mission assignment for us with PBS (Public Broadcasting Television Station) and the Discovery Channel. A division of our production team are documentary film makers. We believe in your work and would like to provide public access to your innovative research. Thank you very much for your consideration on our offer.
[...] http://ouroboros.wordpress.com/2008/11/16/telomerase-expression-slows-aging/ [...]
Well, it is fine, but how about the other options we have here? Would you mind publishing a further post about all of them also? Many thanks!
If sirtuins are good for diabetes then Why the french people who consumes more red wine containing resveratrol are also at high risk of diabetes???
Can you give me some good references describing importance of sirtuins in diabetes please….
Hi,
i hav tried Cawthons method for telomere analysis,using primers of 2002 pub;ished paper,and i couldnt get proper melting curve and the cT value after 22 cyles, (and in paper 11 cycles),and changed primers to tel 1b and tel 2b.I’m bit not satisfied with the results obtained and i couldnt understand i one could get the melting curve analysis as single peak as the extended primers of diff length should give varied length and varied melting curve? I need help in solving the issues.
[...] about FOXO and its effects on aging here at the Ouroboros blog This entry was posted in Life. Bookmark the permalink. ← Quick Breaded zucchini (side [...]
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[...] Low-dose resveratrol as a … low dose of resveratrol (4.9 mg/kg per day), or a calorie restricted (CR … benefits as long-term CR, does low-dose resveratrol … to “Low-dose resveratrol as a calorie restriction … [...]
Lamo blocks voltage dep Na+ channels interacting at the alpha unit of the pore forming unit.It also inhibits Glutamate release. Though its a metabolic suppressor it causes no weight gain and unlike most AED is not GABAnergic. What I love is I’ve prescribed and cured treatment resistant depression of a host of patients with this beautiful drug. It gives a slight mood lift even in healthy individuals in low doses. I’m only concerned with the deadly rash it can cause so go slow , start at 25mg for 2 wks then 50mg for 2 and then 100 , increase further if u want by 50mg every 2 wks.Of course if u get a rash stop and later start and go even slower.The cognitive impairment is negligible compared to other AED like Topiramate. You can take vinpocetine or Ginkgo or piracetam with it.
Awesome blog, I just found in my email. Looking forward to see more.
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All Good morning! Come on site Also swing!
I think it depends if it was poured or drank. If you pour it its half full. If you drank it its half empty.
lXnPIx http://gdjI3b7VaWpU1m0dGpvjRrcu9Fk.com
LOVE THIS SO MUCH.OUR PERCEPTION OF LIFE DETERMINES OUR ALTITUDE .
it was much use full.
у вашего блога смачный дизайн, сами верстали?
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[...] Not so fast, daf-2: IGF-I is all kinds of good for you « OuroborosBoth for the fundamental science of biogerontology and for the human health implications, it seems essential to parse the contributions of IGF-I to programming short lifespans on the one hand, and protecting against age-related decline on the other… [...]
[...] Science radio for scientists « OuroborosThere are a number of good science-related shows on Public Radio: Science Friday, Radiolab, and Tech Nation top my personal list, and there are many others. … Does anyone else have a science-for-scientists podcasts they’d like to share? [...]
it is much useful.
Dear Sirs,
I would appreciate to be registered for attendant to the RoSyBa conference and eventually to present some posters. Thank you in advance.
Daniel V. Guebel
[...] Interested in more? Check out this great article on Ourobouros full of links that explore mitochondria’s role in aging. [...]
Daniel – this isn’t the conference website; we can’t register you.
To register you have to visit this link:
http://goethe.informatik.uni-rostock.de/ibima/rosyba2011/
[...] discusses an interesting discovery which reveals another piece of the puzzle about the genetics of familial [...]
I’ll get right on that, Nancy.
Hi you are clearly a deep expert in this I would like to ask a simpler question–perhaps healthy people who are going to live longer anyway just like to do and enjoy exercise more than unhealthy people? Whats cause and effect here?
I would add that in most of the world rest is considered healthful and exercise is anathema.
I doubt there has been a study that can control for that because you would have to take a random population of non or mild exercisers and have a group exercise more for their entire lives to measure lifespan. Difficult and expensive. On the extreme end it seems obesity amd shortened lifespan is clearly linked.
I have been going to the gym simce a teenager and I certainly subscribe to the endorphin effects.
My mate consistently spoke about this web site but yet this is actually the first page I’ve truly gone through up to now. I’m quite impressed and so now a admirer.
I think you’ve missed the main point of cryonics. There is such a thing as whole-body preservation in cryonics, but to my knowledge the majority of people choose the head-only option.
The reason isn’t because these people speculate on getting their frozen head reattached to a new body, but they actually hope that the information patterns in their brains stay intact enough to be reconstructed and emulated on a computer/robot. If you have a reductionist worldview (which is the one and only scientifically sound worldview as of now) then there is no problem with this approach and we could reconstruct and upload a brain into a computer, and that upload would then be you – you’d be dead and wake up in new body and not even notice the difference at first, because all your memories and your personality would be intact, if the information has remained intact enough. You would have switched the medium but it would still be you and you would still feel like yourself.
There is nothing known in the laws of physics that would prohibit this from working – but that said, I haven’t seen conclusive evidence that our current preservation technology (liquid nitrogen) really preserves the brain well enough for a reconstruction. The question is also “how well is well enough” – do you have to reconstruct a brain down to the molecular level, or does the cellular level suffice? Still, I’d take my chances if there actually was a company that offered me the option of cryonics in my country.
In conclusion, you’ve missed the main point of cryonics: Most (or at least most reasonable) cryonicists don’t really expect to be reawakened in their old body, many just want their brains uploaded into a new body and afterwards continue their new life in the future. There’s nothing unreasonable about taking that gamble with the grim reaper – even if your chances of survival and reconstruction were as low as 5%, this still beats the 100% chance that you’re dead if you just let your corpse rot or burn instead.
[...] biology/network inference in yeast: http://ouroboros.wordpress.com/2…Reducing ribisomal biosynthesis: [...]
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great you rake it to live longer, but forget where you live
(well thats the way I read it)
michelle williams boyfriend,
[...] Rapamycin: “An anti-aging drug today”? (3/6/07) – Ouroboros blog post [...]
I currently have a friend taking metformin, and this is information she did not know. She is diabetic has been taking this for quite some time, but I guess it is to early for me to notice these results.
There is always a new coming into the market and I don’t know if that is a good thing or a bad thing. Has anybody heard or experience any negative results from taking metformin???
I have started Metformin as an anti aging agent. The results are not good. My fasting glucose previousily in the mid 80s and now are high 90s. I also feel at times like I have vertigo, but usually just a dizzy feeling. Is this response common at first? My doctor is cooperating with me in this “experiment” and we don’t have an answer yet why the strange affect.
Hey sorry about this stupid question but what does it mean by median lifespan? Thanks
[...] Biochemistry If you took 2,2-dinitrophenol, could you actually feel comfortable in cold weather?http://ouroboros.wordpress.com/2… shows that dinitrophenol can actually be anti-aging.It's only toxic because it heats you up. [...]
there was an experiment in which one group of mice was fed too much and the other under calories restriction. the thinner mice lived longer than the very fat mice, but no longer than normal mice.
so cr isn’t really the foundation of youth. it just prevents heart attacks and cancer caused by too much fat. the same results could be achieved by not overfeeding the mice, instead of a sever cr.
besides, humans can’t stand it for a long time.
[...] a useful professional assessment of these results: Sirtuin activators as anti-diabetes drugs, and beyond (11/29/07) More: Sirtris Drug May Slow Aging, Create ‘Armstrong’ Cells [...]
[...] minor site update was spurred by my noticing that research blog Ouroboros briefly roused from its slumber to speak about Pathobioliogy of Aging & Age-related Diseases, a new open access journal on [...]
[...] minor site update was spurred by my noticing that research blog Ouroboros briefly roused from its slumber to speak about Pathobioliogy of Aging & Age-related Diseases, a new open access journal on [...]