From the mailbag:
You are kindly invited to the Baltic Sea, for the
*RoSyBA: Rostock Symposium on Systems Biology and Bioinformatics in Ageing Research*
15th-17th September 2011 (Rostock, Germany)Confirmed speakers: Stuart Kim (Stanford), Ann Brunet (Stanford), Jan Hoeijmakers (Rotterdam), Günter Lepperdinger (Innsbruck), Aubrey de Grey (Cambridge), Joao Pedro de Magalhaes (Liverpool), Thomas von Zglinicki (Newcastle), ….
URL: http://goethe.informatik.uni-rostock.de/ibima/rosyba2011/
Early Registration: until June 15, 2011 – Save up to 100%
Call for Contributions: deadline June 1, 2011
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Sign in now[...] Melanie recently summarized some important themes in aging research that were discussed at the second Bay Area Aging Meeting: [...]
[...] IEET [and] recently summarized some important themes in aging research that were discussed at the second Bay Area Aging Meeting. … Two interesting talks concerned UCP2 (mitochondrial uncoupling protein 2) an enzyme which [...]
[...] Bay Area Aging Meeting: Session I Cognitive decline occurs with age: speed of processing, working memory, and long-term memory all decline. Presumably cell loss is partially to blame – not only loss of neurons, but also other types of cells (e.g., oligodendrocytes). Neural stem cells (NSC) can regenerate lost cells to some extent, but their ability to do so diminishes with age. [...]
[...] Bay Area Aging Meeting: Session IV If aging is an engineering problem, then we should be able to solve the engineering challenges more easily in simple systems. By introducing genes from a long-lived organism into the genome of a short-lived organism, it should be possible to add pro-longevity functions – in effect “upgrading” the short-lived animal so that it lives longer. Sagi has set out to do just that, by transferring genes from the long-lived zebrafish (4-year lifespan) to the short-lived worm (4-week lifespan). [...]
Valerie.. you may have celiac, which could inhibit Igf-1 production. Celiac can cause malnutrition.. also.. diabetes & celiac seem to have some cooerlation??? It is possible you are GH resistant, therefore GH therapy will do you no good. Direct Igf-1 therapy could do the trick, however a gluten free diet could be the cure!! Good luck! I hope you get feeling better soon.
We are presently going through all this with my son. Lisa M
hi there
i like the website as i am interested in the science and use to be a research agronomist.
i found the following interesting an on topic
Mannoheptulose: glycolytic inhibitor and novel caloric restriction mimetic George Roth1, Mike Hayek2, Stefan Massimino2, Gary Davenport2, Robert Arking3, Andrzej Bartke4, Michael Bonkowski4 and Don Ingram5
Caloric restriction (CR) is the most robust and reproducible strategy for retarding aging. Benefits of CR have been demonstrated in multiple species, but application to human or companion animal aging represents a challenge. In 1998 the concept of CR “mimetic” (CRM) was introduced as a method to obtain “anti-aging” and health-promoting benefits of CR without reducing food intake. We hypothesized that an effective CRM would best mimic the effects of CR if it impeded initial stages of energy metabolism. We focused initially on glycolytic inhibition using 2-deoxyglucose (2DG). Upon entry into cells, this glucose analog is phosphorylated and becomes a strong competitive inhibitor of phosphohexose isomerase. 2DG effectively induces a CR-like state in rats based on metabolic effects such as reduced plasma glucose, insulin, body temperature, pulse, heart rate and inhibiting tumor growth. Results show 2DG has a narrow window between efficacy and toxicity so recently we shifted our focus to mannoheptulose (MH), a seven-carbon sugar that reduces glycolysis via hexokinase inhibition. MH appears non-toxic with negligible effects on food intake and BW, and increased insulin tolerance by 25% in mice. MH extends median and maximal lifespan (~15%) in D. melanogaster and median lifespan (~30%) in C3H/HeJ mice. These findings, coupled with simple extraction from avocados, suggest that MH may be a practical, highly effective CRM.
the amount of avocado which needs to be taken as far as i can calculate is about one large avocado a day
here is the abstract of the mannoheptulose paper,I could not find a copy of the complete paper. a 30% increase in longevity of mice is not a bad first go
http://www.fasebj.org/cgi/content/meeting_abstract/23/1_MeetingAbstracts/553.1
i posted this elsewhere on the site but this might be the right place
hi there
i like the website as i am interested in the science and use to be a research agronomist.
i found the following interesting an on topic
Mannoheptulose: glycolytic inhibitor and novel caloric restriction mimetic George Roth1, Mike Hayek2, Stefan Massimino2, Gary Davenport2, Robert Arking3, Andrzej Bartke4, Michael Bonkowski4 and Don Ingram5
Caloric restriction (CR) is the most robust and reproducible strategy for retarding aging. Benefits of CR have been demonstrated in multiple species, but application to human or companion animal aging represents a challenge. In 1998 the concept of CR “mimetic” (CRM) was introduced as a method to obtain “anti-aging” and health-promoting benefits of CR without reducing food intake. We hypothesized that an effective CRM would best mimic the effects of CR if it impeded initial stages of energy metabolism. We focused initially on glycolytic inhibition using 2-deoxyglucose (2DG). Upon entry into cells, this glucose analog is phosphorylated and becomes a strong competitive inhibitor of phosphohexose isomerase. 2DG effectively induces a CR-like state in rats based on metabolic effects such as reduced plasma glucose, insulin, body temperature, pulse, heart rate and inhibiting tumor growth. Results show 2DG has a narrow window between efficacy and toxicity so recently we shifted our focus to mannoheptulose (MH), a seven-carbon sugar that reduces glycolysis via hexokinase inhibition. MH appears non-toxic with negligible effects on food intake and BW, and increased insulin tolerance by 25% in mice. MH extends median and maximal lifespan (~15%) in D. melanogaster and median lifespan (~30%) in C3H/HeJ mice. These findings, coupled with simple extraction from avocados, suggest that MH may be a practical, highly effective CRM.
for abstract
http://www.fasebj.org/cgi/content/meeting_abstract/23/1_MeetingAbstracts/553.1
the amount of avocado which needs to be taken as far as i can calculate is about one large avocado a day
[...] seems that SENS theorist Aubrey de Grey, who is chronologically 45, (BioBarCamp photo by Ricardo) is taking roughly the above position in a recent interview. Aubrey [...]
Howdy! This post could not be written any better! Reading through this post reminds me of my old room mate! He always kept talking about this. I will forward this article to him. Pretty sure he will have a good read. Many thanks for sharing!
Does anyone know of a distributor of this compound for research?
I’d like to know that myself. More on the chemical structure is available in Wikipedia’s plastoquinone article (SkQ1 is plastoquinonyl-decyl-triphenylphosphonium). I can’t find a commercial source. Skulachev and co-workers may be making it themselves.
[...] http://ouroboros.wordpress.com/2008/11/16/telomerase-expression-slows-aging/ [...]
If sirtuins are good for diabetes then Why the french people who consumes more red wine containing resveratrol are also at high risk of diabetes???
Can you give me some good references describing importance of sirtuins in diabetes please….
Hi,
i hav tried Cawthons method for telomere analysis,using primers of 2002 pub;ished paper,and i couldnt get proper melting curve and the cT value after 22 cyles, (and in paper 11 cycles),and changed primers to tel 1b and tel 2b.I’m bit not satisfied with the results obtained and i couldnt understand i one could get the melting curve analysis as single peak as the extended primers of diff length should give varied length and varied melting curve? I need help in solving the issues.
[...] about FOXO and its effects on aging here at the Ouroboros blog This entry was posted in Life. Bookmark the permalink. ← Quick Breaded zucchini (side [...]
[...] A box of biologists: The Life Scientists room at FriendFeed (ouroboros.wordpress.com) [...]
[...] Low-dose resveratrol as a … low dose of resveratrol (4.9 mg/kg per day), or a calorie restricted (CR … benefits as long-term CR, does low-dose resveratrol … to “Low-dose resveratrol as a calorie restriction … [...]
Lamo blocks voltage dep Na+ channels interacting at the alpha unit of the pore forming unit.It also inhibits Glutamate release. Though its a metabolic suppressor it causes no weight gain and unlike most AED is not GABAnergic. What I love is I’ve prescribed and cured treatment resistant depression of a host of patients with this beautiful drug. It gives a slight mood lift even in healthy individuals in low doses. I’m only concerned with the deadly rash it can cause so go slow , start at 25mg for 2 wks then 50mg for 2 and then 100 , increase further if u want by 50mg every 2 wks.Of course if u get a rash stop and later start and go even slower.The cognitive impairment is negligible compared to other AED like Topiramate. You can take vinpocetine or Ginkgo or piracetam with it.
I think it depends if it was poured or drank. If you pour it its half full. If you drank it its half empty.
lXnPIx http://gdjI3b7VaWpU1m0dGpvjRrcu9Fk.com
LOVE THIS SO MUCH.OUR PERCEPTION OF LIFE DETERMINES OUR ALTITUDE .
it was much use full.
у вашего блога смачный дизайн, сами верстали?
происхождение фамилии варламов
[...] Not so fast, daf-2: IGF-I is all kinds of good for you « OuroborosBoth for the fundamental science of biogerontology and for the human health implications, it seems essential to parse the contributions of IGF-I to programming short lifespans on the one hand, and protecting against age-related decline on the other… [...]
[...] Science radio for scientists « OuroborosThere are a number of good science-related shows on Public Radio: Science Friday, Radiolab, and Tech Nation top my personal list, and there are many others. … Does anyone else have a science-for-scientists podcasts they’d like to share? [...]
it is much useful.
Dear Sirs,
I would appreciate to be registered for attendant to the RoSyBa conference and eventually to present some posters. Thank you in advance.
Daniel V. Guebel
[...] Interested in more? Check out this great article on Ourobouros full of links that explore mitochondria’s role in aging. [...]
Daniel – this isn’t the conference website; we can’t register you.
To register you have to visit this link:
http://goethe.informatik.uni-rostock.de/ibima/rosyba2011/
[...] discusses an interesting discovery which reveals another piece of the puzzle about the genetics of familial [...]
I’ll get right on that, Nancy.
Hi you are clearly a deep expert in this I would like to ask a simpler question–perhaps healthy people who are going to live longer anyway just like to do and enjoy exercise more than unhealthy people? Whats cause and effect here?
I would add that in most of the world rest is considered healthful and exercise is anathema.
I doubt there has been a study that can control for that because you would have to take a random population of non or mild exercisers and have a group exercise more for their entire lives to measure lifespan. Difficult and expensive. On the extreme end it seems obesity amd shortened lifespan is clearly linked.
I have been going to the gym simce a teenager and I certainly subscribe to the endorphin effects.
My mate consistently spoke about this web site but yet this is actually the first page I’ve truly gone through up to now. I’m quite impressed and so now a admirer.
I think you’ve missed the main point of cryonics. There is such a thing as whole-body preservation in cryonics, but to my knowledge the majority of people choose the head-only option.
The reason isn’t because these people speculate on getting their frozen head reattached to a new body, but they actually hope that the information patterns in their brains stay intact enough to be reconstructed and emulated on a computer/robot. If you have a reductionist worldview (which is the one and only scientifically sound worldview as of now) then there is no problem with this approach and we could reconstruct and upload a brain into a computer, and that upload would then be you – you’d be dead and wake up in new body and not even notice the difference at first, because all your memories and your personality would be intact, if the information has remained intact enough. You would have switched the medium but it would still be you and you would still feel like yourself.
There is nothing known in the laws of physics that would prohibit this from working – but that said, I haven’t seen conclusive evidence that our current preservation technology (liquid nitrogen) really preserves the brain well enough for a reconstruction. The question is also “how well is well enough” – do you have to reconstruct a brain down to the molecular level, or does the cellular level suffice? Still, I’d take my chances if there actually was a company that offered me the option of cryonics in my country.
In conclusion, you’ve missed the main point of cryonics: Most (or at least most reasonable) cryonicists don’t really expect to be reawakened in their old body, many just want their brains uploaded into a new body and afterwards continue their new life in the future. There’s nothing unreasonable about taking that gamble with the grim reaper – even if your chances of survival and reconstruction were as low as 5%, this still beats the 100% chance that you’re dead if you just let your corpse rot or burn instead.
[...] biology/network inference in yeast: http://ouroboros.wordpress.com/2…Reducing ribisomal biosynthesis: [...]
[...] inference in yeast: http://ouroboros.wordpress.com/2…Reducing ribisomal biosynthesis: http://ouroboros.wordpress.com/2…Bookshttp://www.amazon.com/Major-Issu... – major issues in cognitive [...]
great you rake it to live longer, but forget where you live
(well thats the way I read it)
michelle williams boyfriend,
[...] Rapamycin: “An anti-aging drug today”? (3/6/07) – Ouroboros blog post [...]
I currently have a friend taking metformin, and this is information she did not know. She is diabetic has been taking this for quite some time, but I guess it is to early for me to notice these results.
There is always a new coming into the market and I don’t know if that is a good thing or a bad thing. Has anybody heard or experience any negative results from taking metformin???
I have started Metformin as an anti aging agent. The results are not good. My fasting glucose previousily in the mid 80s and now are high 90s. I also feel at times like I have vertigo, but usually just a dizzy feeling. Is this response common at first? My doctor is cooperating with me in this “experiment” and we don’t have an answer yet why the strange affect.
Hey sorry about this stupid question but what does it mean by median lifespan? Thanks
[...] Biochemistry If you took 2,2-dinitrophenol, could you actually feel comfortable in cold weather?http://ouroboros.wordpress.com/2… shows that dinitrophenol can actually be anti-aging.It's only toxic because it heats you up. [...]
there was an experiment in which one group of mice was fed too much and the other under calories restriction. the thinner mice lived longer than the very fat mice, but no longer than normal mice.
so cr isn’t really the foundation of youth. it just prevents heart attacks and cancer caused by too much fat. the same results could be achieved by not overfeeding the mice, instead of a sever cr.
besides, humans can’t stand it for a long time.
[...] a useful professional assessment of these results: Sirtuin activators as anti-diabetes drugs, and beyond (11/29/07) More: Sirtris Drug May Slow Aging, Create ‘Armstrong’ Cells [...]
[...] minor site update was spurred by my noticing that research blog Ouroboros briefly roused from its slumber to speak about Pathobioliogy of Aging & Age-related Diseases, a new open access journal on [...]
[...] minor site update was spurred by my noticing that research blog Ouroboros briefly roused from its slumber to speak about Pathobioliogy of Aging & Age-related Diseases, a new open access journal on [...]