After a great deal of early promise, resveratrol has been on the ropes for a while, most prominently as a result of studies questioning whether it can directly activate sirtuins — this against a backdrop of growing skepticism that sirtuin activation can extend mammalian lifespan in any case.
Now, another (possible) black eye: GlaxoSmithKline (the company that purchased Sirtris, a pharmaceutical company co-founded by sirtuin/resveratrol pioneer David Sinclair) has suspended a trial of a resveratrol formulation, SRT501 in multiple myeloma patients, because several of the study’s subjects developed kidney failure.
GSK emphasizes that the trial has not been cancelled, but they are observing a moratorium on recruiting new patients until they determine whether the resveratrol was responsible for the subjects’ kidney problems. Nephropathy is a frequent complication in myeloma; one hypothesis being entertained is that the very high doses of resveratrol used in the trial caused vomiting, which in turn resulted in dehydration and tipped the balance in kidneys already close to failure due to the underlying cancer.
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Sign in nowLamo blocks voltage dep Na+ channels interacting at the alpha unit of the pore forming unit.It also inhibits Glutamate release. Though its a metabolic suppressor it causes no weight gain and unlike most AED is not GABAnergic. What I love is I’ve prescribed and cured treatment resistant depression of a host of patients with this beautiful drug. It gives a slight mood lift even in healthy individuals in low doses. I’m only concerned with the deadly rash it can cause so go slow , start at 25mg for 2 wks then 50mg for 2 and then 100 , increase further if u want by 50mg every 2 wks.Of course if u get a rash stop and later start and go even slower.The cognitive impairment is negligible compared to other AED like Topiramate. You can take vinpocetine or Ginkgo or piracetam with it.
I think it depends if it was poured or drank. If you pour it its half full. If you drank it its half empty.
LOVE THIS SO MUCH.OUR PERCEPTION OF LIFE DETERMINES OUR ALTITUDE .
Dear Sirs,
I would appreciate to be registered for attendant to the RoSyBa conference and eventually to present some posters. Thank you in advance.
Daniel V. Guebel
Daniel – this isn’t the conference website; we can’t register you.
To register you have to visit this link:
http://goethe.informatik.uni-rostock.de/ibima/rosyba2011/
[...] discusses an interesting discovery which reveals another piece of the puzzle about the genetics of familial [...]
I’ll get right on that, Nancy.
Hi you are clearly a deep expert in this I would like to ask a simpler question–perhaps healthy people who are going to live longer anyway just like to do and enjoy exercise more than unhealthy people? Whats cause and effect here?
I would add that in most of the world rest is considered healthful and exercise is anathema.
I doubt there has been a study that can control for that because you would have to take a random population of non or mild exercisers and have a group exercise more for their entire lives to measure lifespan. Difficult and expensive. On the extreme end it seems obesity amd shortened lifespan is clearly linked.
I have been going to the gym simce a teenager and I certainly subscribe to the endorphin effects.
My mate consistently spoke about this web site but yet this is actually the first page I’ve truly gone through up to now. I’m quite impressed and so now a admirer.
I think you’ve missed the main point of cryonics. There is such a thing as whole-body preservation in cryonics, but to my knowledge the majority of people choose the head-only option.
The reason isn’t because these people speculate on getting their frozen head reattached to a new body, but they actually hope that the information patterns in their brains stay intact enough to be reconstructed and emulated on a computer/robot. If you have a reductionist worldview (which is the one and only scientifically sound worldview as of now) then there is no problem with this approach and we could reconstruct and upload a brain into a computer, and that upload would then be you – you’d be dead and wake up in new body and not even notice the difference at first, because all your memories and your personality would be intact, if the information has remained intact enough. You would have switched the medium but it would still be you and you would still feel like yourself.
There is nothing known in the laws of physics that would prohibit this from working – but that said, I haven’t seen conclusive evidence that our current preservation technology (liquid nitrogen) really preserves the brain well enough for a reconstruction. The question is also “how well is well enough” – do you have to reconstruct a brain down to the molecular level, or does the cellular level suffice? Still, I’d take my chances if there actually was a company that offered me the option of cryonics in my country.
In conclusion, you’ve missed the main point of cryonics: Most (or at least most reasonable) cryonicists don’t really expect to be reawakened in their old body, many just want their brains uploaded into a new body and afterwards continue their new life in the future. There’s nothing unreasonable about taking that gamble with the grim reaper – even if your chances of survival and reconstruction were as low as 5%, this still beats the 100% chance that you’re dead if you just let your corpse rot or burn instead.
[...] biology/network inference in yeast: http://ouroboros.wordpress.com/2…Reducing ribisomal biosynthesis: [...]
[...] inference in yeast: http://ouroboros.wordpress.com/2…Reducing ribisomal biosynthesis: http://ouroboros.wordpress.com/2…Bookshttp://www.amazon.com/Major-Issu... – major issues in cognitive [...]
great you rake it to live longer, but forget where you live
(well thats the way I read it)
[...] Rapamycin: “An anti-aging drug today”? (3/6/07) – Ouroboros blog post [...]
I currently have a friend taking metformin, and this is information she did not know. She is diabetic has been taking this for quite some time, but I guess it is to early for me to notice these results.
There is always a new coming into the market and I don’t know if that is a good thing or a bad thing. Has anybody heard or experience any negative results from taking metformin???
I have started Metformin as an anti aging agent. The results are not good. My fasting glucose previousily in the mid 80s and now are high 90s. I also feel at times like I have vertigo, but usually just a dizzy feeling. Is this response common at first? My doctor is cooperating with me in this “experiment” and we don’t have an answer yet why the strange affect.
Hey sorry about this stupid question but what does it mean by median lifespan? Thanks
[...] Biochemistry If you took 2,2-dinitrophenol, could you actually feel comfortable in cold weather?http://ouroboros.wordpress.com/2… shows that dinitrophenol can actually be anti-aging.It's only toxic because it heats you up. [...]
there was an experiment in which one group of mice was fed too much and the other under calories restriction. the thinner mice lived longer than the very fat mice, but no longer than normal mice.
so cr isn’t really the foundation of youth. it just prevents heart attacks and cancer caused by too much fat. the same results could be achieved by not overfeeding the mice, instead of a sever cr.
besides, humans can’t stand it for a long time.
[...] a useful professional assessment of these results: Sirtuin activators as anti-diabetes drugs, and beyond (11/29/07) More: Sirtris Drug May Slow Aging, Create ‘Armstrong’ Cells [...]
[...] minor site update was spurred by my noticing that research blog Ouroboros briefly roused from its slumber to speak about Pathobioliogy of Aging & Age-related Diseases, a new open access journal on [...]
[...] minor site update was spurred by my noticing that research blog Ouroboros briefly roused from its slumber to speak about Pathobioliogy of Aging & Age-related Diseases, a new open access journal on [...]