From the mailbag, news of a new aging-related peer-reviewed journal, currently in its first issue: Pathobiology of Aging & Age-related Diseases. I haven’t had to check it out yet, but it looks like it will be of broad interest to biogerontologists from a variety of disciplines. The editorial board includes quite a few luminaries of the field, so it seems promising.
In their own words:
Aims: Pathobiology of Aging & Age-related Diseases (PBA) is a new peer reviewed journal serving as a forum for researchers to communicate pathology data as a primary scientific focus of aging; data that might be of less interest in other journals more focused on generic aging or specific scientific disciplines. We are especially interested in developing a focus for advancing the pathological basis of aging in mammalian systems, in particular the mouse and humans.
Scope: Pathobiology of Aging & Age-related Diseases is interdisciplinary in nature and covers all aspects of pathology of aging related to disease phenotypes including cancer, cardiovascular disease, neurological disorders, metabolic dysfunction, renal and gastrointestinal disorders, endocrine dysfunction, musculoskeletal conditions and skin disorders. The underlying theme is based on the sound scientific principles of the pathogenesis of aging and age-related diseases as well as intervention data with resolution of pathological endpoints. The emphasis will be on preclinical studies as well as clinical studies related to strategies developed in animal models and will be image intensive. Papers on the basic biology of aging in invertebrates will not be considered unless comparative mammalian data is also included.
We welcome Research papers, Review articles, Brief reports, Case reports, New animal models, Technical reports, Images, PhD thesis Summaries, and Commentaries.
Target groups: Anatomical and molecular pathologists, gerontologists, geriatricians, transgenic mouse geneticists, toxicologists, and scientists, veterinarians and physicians focused on basic and clinical research in cardiovascular disease, cancer, gastrointestinal disease, endocrine disorders, metabolic dysfunction, renal disease, neurological disorders including Alzheimer’s disease, skin disorders, and musculoskeletal disease.
PBA is open-access; the publisher, Co-Action Press, is a relatively new entity whose small but growing stable consists entirely of open-access journals spanning a wide range of fields.
My personal feeling is that there are probably already too many journals, mostly because I don’t think I or my colleagues actually interact with journals as entities. Mostly we just do literature searches, and choose papers to read based on titles and abstracts. The exception is when we’re submitting papers, but then the diversity of formats and author requirements creates obstacles to rapid submission (and re-submission, if necessary).
I wouldn’t mind seeing individual journals be replaced by a robust tagging system on a relatively laissez-faire neo-journal such as PLoS ONE (to allow scholars to create communities and filters on the firehose of new papers), and a little time spent teaching everyone how to set up PubMed RSS feeds. That said, if we’re going to start new enterprises, this is probably the right way to go, so good luck to PBA.
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Sign in nowLamo blocks voltage dep Na+ channels interacting at the alpha unit of the pore forming unit.It also inhibits Glutamate release. Though its a metabolic suppressor it causes no weight gain and unlike most AED is not GABAnergic. What I love is I’ve prescribed and cured treatment resistant depression of a host of patients with this beautiful drug. It gives a slight mood lift even in healthy individuals in low doses. I’m only concerned with the deadly rash it can cause so go slow , start at 25mg for 2 wks then 50mg for 2 and then 100 , increase further if u want by 50mg every 2 wks.Of course if u get a rash stop and later start and go even slower.The cognitive impairment is negligible compared to other AED like Topiramate. You can take vinpocetine or Ginkgo or piracetam with it.
I think it depends if it was poured or drank. If you pour it its half full. If you drank it its half empty.
LOVE THIS SO MUCH.OUR PERCEPTION OF LIFE DETERMINES OUR ALTITUDE .
Dear Sirs,
I would appreciate to be registered for attendant to the RoSyBa conference and eventually to present some posters. Thank you in advance.
Daniel V. Guebel
Daniel – this isn’t the conference website; we can’t register you.
To register you have to visit this link:
http://goethe.informatik.uni-rostock.de/ibima/rosyba2011/
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I’ll get right on that, Nancy.
Hi you are clearly a deep expert in this I would like to ask a simpler question–perhaps healthy people who are going to live longer anyway just like to do and enjoy exercise more than unhealthy people? Whats cause and effect here?
I would add that in most of the world rest is considered healthful and exercise is anathema.
I doubt there has been a study that can control for that because you would have to take a random population of non or mild exercisers and have a group exercise more for their entire lives to measure lifespan. Difficult and expensive. On the extreme end it seems obesity amd shortened lifespan is clearly linked.
I have been going to the gym simce a teenager and I certainly subscribe to the endorphin effects.
My mate consistently spoke about this web site but yet this is actually the first page I’ve truly gone through up to now. I’m quite impressed and so now a admirer.
I think you’ve missed the main point of cryonics. There is such a thing as whole-body preservation in cryonics, but to my knowledge the majority of people choose the head-only option.
The reason isn’t because these people speculate on getting their frozen head reattached to a new body, but they actually hope that the information patterns in their brains stay intact enough to be reconstructed and emulated on a computer/robot. If you have a reductionist worldview (which is the one and only scientifically sound worldview as of now) then there is no problem with this approach and we could reconstruct and upload a brain into a computer, and that upload would then be you – you’d be dead and wake up in new body and not even notice the difference at first, because all your memories and your personality would be intact, if the information has remained intact enough. You would have switched the medium but it would still be you and you would still feel like yourself.
There is nothing known in the laws of physics that would prohibit this from working – but that said, I haven’t seen conclusive evidence that our current preservation technology (liquid nitrogen) really preserves the brain well enough for a reconstruction. The question is also “how well is well enough” – do you have to reconstruct a brain down to the molecular level, or does the cellular level suffice? Still, I’d take my chances if there actually was a company that offered me the option of cryonics in my country.
In conclusion, you’ve missed the main point of cryonics: Most (or at least most reasonable) cryonicists don’t really expect to be reawakened in their old body, many just want their brains uploaded into a new body and afterwards continue their new life in the future. There’s nothing unreasonable about taking that gamble with the grim reaper – even if your chances of survival and reconstruction were as low as 5%, this still beats the 100% chance that you’re dead if you just let your corpse rot or burn instead.
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great you rake it to live longer, but forget where you live
(well thats the way I read it)
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I currently have a friend taking metformin, and this is information she did not know. She is diabetic has been taking this for quite some time, but I guess it is to early for me to notice these results.
There is always a new coming into the market and I don’t know if that is a good thing or a bad thing. Has anybody heard or experience any negative results from taking metformin???
I have started Metformin as an anti aging agent. The results are not good. My fasting glucose previousily in the mid 80s and now are high 90s. I also feel at times like I have vertigo, but usually just a dizzy feeling. Is this response common at first? My doctor is cooperating with me in this “experiment” and we don’t have an answer yet why the strange affect.
Hey sorry about this stupid question but what does it mean by median lifespan? Thanks
[...] Biochemistry If you took 2,2-dinitrophenol, could you actually feel comfortable in cold weather?http://ouroboros.wordpress.com/2… shows that dinitrophenol can actually be anti-aging.It's only toxic because it heats you up. [...]
there was an experiment in which one group of mice was fed too much and the other under calories restriction. the thinner mice lived longer than the very fat mice, but no longer than normal mice.
so cr isn’t really the foundation of youth. it just prevents heart attacks and cancer caused by too much fat. the same results could be achieved by not overfeeding the mice, instead of a sever cr.
besides, humans can’t stand it for a long time.
[...] a useful professional assessment of these results: Sirtuin activators as anti-diabetes drugs, and beyond (11/29/07) More: Sirtris Drug May Slow Aging, Create ‘Armstrong’ Cells [...]
[...] minor site update was spurred by my noticing that research blog Ouroboros briefly roused from its slumber to speak about Pathobioliogy of Aging & Age-related Diseases, a new open access journal on [...]
[...] minor site update was spurred by my noticing that research blog Ouroboros briefly roused from its slumber to speak about Pathobioliogy of Aging & Age-related Diseases, a new open access journal on [...]