Drug Discovery Opinion
News articles relevant to those working in drug discovery and development, covering research in academia and industry in all therapeutic areas.
-
Apr 23, 12 03:13AMWith the rapidly growing body of biostructural information, structure-based drug design has increased in importance and a variety of computational methods have found a place in the drug discovery tool kit...
-
Apr 19, 11 05:41AMScientists at the Scripps Research Institute have reported on compounds that are able to suppress severity and disease progression in animal models of multiple sclerosis. The compounds, exemplified by SR1001...
-
Jan 31, 11 06:05AMBz-423, a mitochondrial F1F0-ATP synthase inhibitor, that has previously shown promise for the treatment of autoimmune disorders such as lupus, arthritis and psoriasis has now been shown to halt the p rogression...
-
Jan 27, 11 01:12AMTool compounds are used to explore the role of a specific protein in a biological context and – it goes without saying – that to obtain meaningful results in a complex situation, the tool compound...
-
Jan 14, 11 12:42AMMultiple sclerosis (MS), believed to be an immune-mediated disorder, is the most common disabling condition of the central nervous system (CNS) affecting young adults. Infiltration of leukocytes into the...
-
Jan 12, 11 04:32AMThe majority of Parkinson’s disease (PD) cases have no known cause, but have been associated with increased oxidative stress and mitochondrial dysfunction. Of the small proportion of hereditary cases...
-
Jan 07, 11 06:57AMDevelopment of cancer is conventionally viewed as a gradual process, taking years to accumulate multiple point mutations and chromosomal rearrangements, and progressing through increasingly malignant phenotypes...
-
Dec 16, 10 01:53AMLast week it was reported that a daily (low) dose of aspirin can significantly reduce the risk of dying from a variety of cancers, and a study published in PloS Biology now opens a new window on the r ole...
-
Nov 16, 10 01:04AMTransient receptor potential (TRP) ion channels mediate a variety of sensations including thermal stimuli. The channels also react to multiple ligands: for example, TRPV1 channels respond to heat as w ell...
-
Nov 15, 10 01:49AMMany chemotherapy drugs, including cisplatin, cause damage to DNA and kill cancer cells by interfering with DNA replication and cell division. The damage activates cellular DNA repair mechanisms but, if...
Showing 1 to 10 of 221 posts