Researchers from the University of Toronto recently conducted a review literature describing the effects of structured individualized physical exercise on bipolar disorder. They "conducted a PubMed search of all English-language articles published between 1966 and July 2008 with BD [bipolar disorder] cross-referenced with the following search terms: exercise, neurobiology, pathophysiology, pathoetiology, brain, cognition, neuroplasticity, and neurodegeneration. Articles selected for review were based on adequacy of sample size, the use of standardized experimental procedures, validated assessment measures, and overall manuscript quality."
The conclusions from their review of previous research in the area, was that "Structured exercise regimens exert a salutary effect on interacting networks mediating metabolism, immuno-inflammatory function, and cellular respiration. In keeping this view, buttressed by controlled evidence describing robust anti-depressant effects with exercise (e.g., public health dose), a testable hypothesis is that structured exercise is capable of improving psychiatric and somatic health in BD." Abstract: PubMed. "Exercise and bipolar disorder: a review of neurobiological mediators," by Alsuwaidan MT, Kucyi A, Law CW, McIntyre RS in NeuroMolecular Medicine [2009;11(4):328-36]
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