A 14 year old female with Trisomy 21 and a new diagnosis of Pre-B ALL is undergoing induction using a modified COG protocol, and is receiving asparaginase (Elspar) to deprive the leukemic cells of essential circulating asparagine. Asparaginase has several known adverse effects, including decreased synthesis of several coagulation and anticoagulation factors, including fibrinogen, antithrombin III and in some cases, proteins C and S.
Posted in Anatomic Pathology, Clinical Pathology Tagged: hematology, oncology
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Sign in nowI already knew this. I learned this in medical school in our second year. I’m pretty sure it was on the USMLE Step 1. But, I’m glad you learned that today.
Bottom line: never ever trust an on-call intern….Amen!
I can dig it.
Please don’t also forget to restick the patient just in case it is a mechanical issue with the stick.
Excellent point, Doctor.