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Mortality after Fluid Bolus in African Children with Severe Infection. Maitland, K et al. New England Journal of Medicine, May 26th 2011 (epub ahead of print) (DOI: 10.1056/NEJMe1105490) An interestin g...
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An interesting editorial published a couple of months ago in Anaesthesia by Neil Soni. It adds to the growing disquiet that our understanding of disease, and attempts to find effective remedies, are b eing...
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A fascinating study from the NEJM. Neuromuscular Blockers in Early ARDS. Papazian, L et al. NEJM. Vol 6, 12, 2010. This RCT gave a 48 hr infusion of cis-atricurium to early (<24hrs) ARDS patients. It...
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We’ve known for sometime that high inspired oxygen fractions (>0.8) are associated with atelechasis (and decruitment / shunt) and lung injury and suspected that hyperoxia also leads to the ge neration...
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First an apology, there’s been quite a gap since my last post. I will be trying my best to increase the frequency of appraisals on Critical Insight, especially since Schringer & Altman&rsquo s...
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Dopamine has been the vasopressor of choice in septic patients in continental europe historically, although this may be changing. Dopamine has theoretically beneficial effects in maintaining splancnic and...
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A fascinating paper very well reviewed by Dr. James Dawson at the QMC journal club; The bispectral index and suppression ratio are very early predictors of neurological outcome during therapeutic hypo thermia...
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The ANZICS group appear to have done it again; that is taken a single centre trial done in Europe, repeated it in a sensible and pragmatic way but in a much larger, adequately powered multi centre set ting...
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Critical Insight has been included as a founding member of Medpedia’s News & Analysis website. Medpedia is an exciting project to build a first class medical resource on the internet using w orld...
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2 recent articles highlight the potential benefit of an often overlooked induction agent in critically ill patients. Etomidate versus ketamine for rapid sequence intubation in acutely ill patient s...
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