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Is Cognex (Tacrine) helpful for Alzheimer's disease?
Female
asked Oct 01, 2010 at 07:39AM in Neurology/Brain Disorders
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1Votes
answered Oct 01, 2010 at 09:58AMIn trials, Tacrine has been found to be slightly helpful in the treatment of Alzheimer's disease, however, it is not preferable because it has a low oral bio-availability, and is thus not absorbed well. Therefore, it is no longer a first line drug in this disease. Patients are now prescribed other acetylcholinesterase inhibitors such as Rivastigmine (exelon) Donepezil (Aricept) and Galantamine (Razadyne). None of these drugs are terribly effective however (only appx 30% respond at all, and even then minimally). The drug does not improve current cognition, but can make the decline in cognition move slightly slower. However, the side effects of the medication are often worse than the decline in cognition that could be offset by the drugs, causing patients to become more agitated. The worst symptom, and most common is diarrhea and gastrointestinal distress. -
0Votes
answered Oct 01, 2010 at 10:50AMTacrine was slightly helpful in the past with lots of side effects and poor efficacy. Nowadays we have other ACHEI more efficacious and with less side effects as donepecil, rivastigmine and galantamine. It´s due to make know that all these medications are symptomatic and only really usefull in the first stages of the disease.
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