answered Sep 02, 2009 at 01:38PM
The influenza virus comes in three types: A, B, and C. Within each type is a subtype or "strain". Each strain is different from one another by their genetic make-up. There are different strains from year-to-year because the the genes in the virus shift and drift. A shift is a slight change in the genetic makeup. However, this is enough to make the virus appear a little bit different to our immune system. A drift, on the other hand, is a larger change in the genetic makeup of the virus. So that virus looks completely different to our immune system. This drift occurred in swine flu when a type A virus combined its genetic makeup with another type A that had swine flu genes in it, and another type A virus that had seasonal flu in it. So now we have this "shifted" virus that is new to our immune system.
That said, it is not new to our medical technology and to what we know about the flu. Sure, we don't have natural immunity for it because we have not been exposed to viruses that are similar, but we still have medications (and a vaccine soon) that will help mitigate its effects.