While Dr. Maggon mentions "documented cases of toxicity" associated with the use of Noni berry juice, I am unaware of any of that. In fact it is clear that this fruit is a staple of the diet of the islanders in the regions of the World where it grows, and there are no reports of which I am aware, that they suffer any toxic effects from consuming it. On the positive side, there are certainly high levels of antioxidants and other beneficial substances in Noni juice, just as there are in many other fruit juices, like Pomegranate juice which all may have some benefits in terms of prevention of coronary artery disease. It is true though, that much research remains to be done to prove any of these claims. If anyone has actual references to negative toxicity studies on noni juice, or any other fruit juice in this category, I would love to review them.

Krishan - Thanks for the references. I certainly did look into this. It seems you are correct that there were some concerns about hepatotoxicity. But from all the studies I reviewed on Pubmed (abt 15 or so) the results showed there was none discovered or provable. Two studies looked at rat embryos and only one of those appears to show possibly "delayed ossification". The other reported no dangers at all. Several more seemed to report that Noni juice has hepato-PROTECTIVE value, and others were looking at angioneogenesis, but I saw no study that supported a significant provable anticancer benefit.
Here are the studies I did think were significant in this argument:

PUBMED.....................................................- FINDING
http://www.ncbi.nlm.nih.gov/pubmed/19797868 - no liver toxicity
http://www.ncbi.nlm.nih.gov/pubmed/19043286 - no danger to fetus
http://www.ncbi.nlm.nih.gov/pubmed/18654853 - hepato protective effects!
http://www.ncbi.nlm.nih.gov/pubmed/20038450 - MAY have cause delayed ossification in RAT embryos

In short; it seems there is really no good evidence that NONI juice is toxic to the liver, or kidneys, but for the present time, I would certainly recommend that pregnant women DO NOT consume it, just to remain on the safe side, though any mutagenic or other negative issues are not yet proved.
It still does appear from what I can glean from all this, that the cardiovascular benefits probably outweigh the dearth of negative outcome studies. Thanks for the challenge.

That's true of all food supplements. But, at the same time I am no fan of letting the FDA control all the vitamin and food supplement industry. We'd become like Europe, where you can;t buy melatonin without a prescription. Where's the happy medium?

Clearly some oversight is required to assure purity and even before that, cleanliness of manufacturing processes. It would seem that licensing the facilities which produce the supplements by way of cleanliness laws is a real good middle ground. But, I understand that there are ISO standards for which labs can apply, and public education should improve as to which to look for on a lable of a product intended for human consumption.

In my opinion there should also be some set of standards for human absorbability of contents; i.e. at the moment only the FTC oversees what goes into such products. Thus, if there are iron filings in a breakfast cereal, the mfg. can say it is "fortified with iron". The public has no way to understand this kind of scam without sophisticated testing. How many studies were done on Vitamin C, with pure ascorbic acid? In nature we never get Vit C, without rutin, hesperidin and bioflavinoids, and absorption is severely affected when they are not present. Etc., etc. This goes on and on. I'm only getting started.