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What does high cholesterol have to do with heart disease?

62 yr old, Male
62 yr old, Male
asked Nov 24, 2009 at 03:55PM in Cardiology/Heart Disease
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  • 2
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    answered Dec 14, 2009 at 07:24AM
    Cholesterol is an essential substance that humans and animals need to produce their cell membranes and transport fat substances through the blood. The problem occurs when there is too much cholesterol. When this happens, the cholesterol gets deposited in the walls of your arteries, where it causes inflammation, damage, and narrowing of the arteries. This happens very commonly in the blood vessels of the heart. When the blood vessels of the heart become blocked, the heart does not get enough oxygen. This can present as chest pain (angina) or as a heart attack. Heart tissue will die if it does not get enough oxygen, and the heart will not be able to pump enough blood.

    Because we want to prevent the ultimate heart tissue death and pumping problems, we target the things that happen early in this cascade, such as high cholesterol. Other important things that we target include smoking (which greatly increases the chances of changes in blood vessels), diabetes, and a baby aspirin daily in an appropriate age group.

    Your physician can help assist you in reducing your cholesterol to appropriate goals.
  • 1
    Votes
    answered Dec 17, 2009 at 06:38PM
    Although I'm a heart attack survivor who now takes statin drugs every day (routinedly prescribed in our Heart Institute for all cardiac patients), I've become increasingly interested in this question.

    There appears to be a growing body of evidence throwing some doubt on the assumption that high LDL (bad) cholesterol numbers and low HDL (good) numbers lead to cardiovascular disease.

    In France, ischaemic heart disease rates are only ONE QUARTER of those in the UK or North America. The major risk factors are no more favourable in France, and the French show similar levels of serum total cholesterol and high density lipoprotein cholesterol concentrations. Reports like this are cause for revisiting our assumptions about cholesterol.

    It's also important to keep in mind that much of the clinical trials and published research linking cholesterol and heart disease have been funded by the very drug companies who manufacture statin drugs for cholesterol management. Statin drugs are the darlings of the drug world (any drug that an otherwise healthy person willingly takes every day for the rest of his/her life is like winning the lottery for Big Pharma). Lipitor, for example, is the biggest selling drug in the world, produced by the biggest drug company in the world, Pfizer.

    My cardiologist points to high-cholesterol food as an example of how science has changed its collective mind over the decades in its attitude towards cholesterol. During the 70s when early cholesterol research results were coming in, the standard clinical advice was that cholesterol - ALL cholesterol - is bad, including any in the food we eat. NO EGGS! Then, as emerging research revealed new results, he said cardiologists began allowing three eggs per week. Now, he says, his patients can eat an eg every day. So cholesterol in our food apparently isn't as deadly as once thought.

    One wonders if the same change might happen one day around those who are pushing statins now to control those cholesterol numbers.
    • I agree with you, Carolyn.
      Gina Pera commented Mar 02, 2010 at 09:42PM
  • 0
    Votes
    answered Feb 06, 2010 at 11:19AM
    I suggest that anyone concerned about cholesterol learn more about magnesium, a "simple" mineral that is vital to our body's healthy functioning but is too often overlooked in favor of medications that can cause more harm than good.

    There are no pharmaceutical reps to recommend this to physicians, who often don't understand basic biochemistry. But the science is sound.

    Magnesium deficiency is associated with hypertension, high cholesterol, mitral-valve prolapse, and many more cardio issues. Simply put, magnesium "relaxes" cells, muscles, tendons, and arteries while calcium "stiffens."

    To learn more, do a Google search for "magnesium + cholesterol." Magnesium research scientist Mildred Seelig wrote an excellent book called The Magnesium Factor. It is rather scientific in nature, but still understandable to the educated reader. A more lay-friendly book is The Miracle of Magnesium by Carolyn Deane.

    I hope this helps!

    Gina Pera, author
    Is It You, Me, or Adult A.D.D.?
  • 0
    Votes
    answered Feb 06, 2010 at 11:21AM
    HI Carolyn,

    You make excellent points! Especially this:

    "My cardiologist points to high-cholesterol food as an example of how science has changed its collective mind over the decades in its attitude towards cholesterol. During the 70s when early cholesterol research results were coming in, the standard clinical advice was that cholesterol - ALL cholesterol - is bad, including any in the food we eat. NO EGGS! Then, as emerging research revealed new results, he said cardiologists began allowing three eggs per week. Now, he says, his patients can eat an eg every day. So cholesterol in our food apparently isn't as deadly as once thought.

    "One wonders if the same change might happen one day around those who are pushing statins now to control those cholesterol numbers.

    ---------
    It is a sad fact of modern medicine that we have many specialists who know a lot about one thing but don't often make connections to other things. In other words, many cardiologists simply do not understand biochemistry!

    Read those books, and you will know more about magnesium's effect on cardiovascuular issues than 90% of cardiovascular specialists.

    Gina
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