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Oxytocin as a treatment for autism

Is there any basis for this? Are there clinical trials currently recruiting for this research?
42 yr old, Female
42 yr old, Female
asked Dec 28, 2009 at 04:27PM in Pediatrics
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    answered Dec 30, 2009 at 07:31AM
    Yes there are studies being done using oxytocin in autism.
    Researcher Eric Hollander and co-researcher Jennifer Bartz from the Mt. Sinai School of Medicine, believes that autism could be a good candidate for treatment with oxytocin as it presents with the types of symptoms that have been found to be associated with oxytocin. "[Past] studies with animals have found that oxytocin plays a role in a variety of behaviors, including parent-child and adult-to-adult pair bonding, social memory, social cognition, anxiety reduction and repetitive behaviors,"
    They have published their work in a some very resected journals.

    Here is the abstract form the journal Neuropsychopharmacology

    Autism is a neurodevelopmental disorder characterized by dysfunction in three core behavioral domains: repetitive behaviors, social deficits, and language abnormalities. There is evidence that abnormalities exist in peptide systems, particularly the oxytocin system, in autism spectrum patients. Furthermore, oxytocin and the closely related peptide vasopressin are known to play a role in social and repetitive behaviors. This study examined the impact of oxytocin on repetitive behaviors in 15 adults with autism or Asperger's disorder via randomized double-blind oxytocin and placebo challenges. The primary outcome measure was an instrument rating six repetitive behaviors: need to know, repeating, ordering, need to tell/ask, self-injury, and touching. Patients with autism spectrum disorders showed a significant reduction in repetitive behaviors following oxytocin infusion in comparison to placebo infusion. Repetitive behavior in autism spectrum disorders may be related to abnormalities in the oxytocin system, and may be partially ameliorated by synthetic oxytocin infusion.
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