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Can alcoholism cause diabetes?
Obesity leads to insulin resistance, directly and through increasing the concentration of free fatty acids (FFA) leading to ectopic fat, leading to fat being stored in the pancreas and more insulin resistance (through SNAP23 not being able to transport GLUT4).
This causes gluco- and lipotoxicity in the pancreas, damaging beta-cells of the pancreas leading to a decrease in insulin excretion.
Decreased insulin excretion together with increased insulin resistance leads to diabetes.
(please do correct me if I'm wrong)
Alcoholism has a number of effects and, as far as I can deduct, some of them should cause diabetes. I've tried searching in literature and on the internet but to no avail.
One of the effects of ethanol is an increase in the secretion of epinephrine which leads to lipolysis which leads to higher concentrations of free fatty acids in the blood.
This can lead to ectopic fat storage which (as far as I can tell) should lead to diabetes? (see top)
At the same time the NADH/NAD+ quota is displaced (increased 5-10 fold) this leads to a decrease in beta oxidation leading to an increase in TAG-synthesis leading to an increase in VLDL, leading to fatty liver and hyperlipidemia.
Shouldn't this also lead to diabetes?
So, can alcoholism through these (or other) mechanisms lead to diabetes?
This causes gluco- and lipotoxicity in the pancreas, damaging beta-cells of the pancreas leading to a decrease in insulin excretion.
Decreased insulin excretion together with increased insulin resistance leads to diabetes.
(please do correct me if I'm wrong)
Alcoholism has a number of effects and, as far as I can deduct, some of them should cause diabetes. I've tried searching in literature and on the internet but to no avail.
One of the effects of ethanol is an increase in the secretion of epinephrine which leads to lipolysis which leads to higher concentrations of free fatty acids in the blood.
This can lead to ectopic fat storage which (as far as I can tell) should lead to diabetes? (see top)
At the same time the NADH/NAD+ quota is displaced (increased 5-10 fold) this leads to a decrease in beta oxidation leading to an increase in TAG-synthesis leading to an increase in VLDL, leading to fatty liver and hyperlipidemia.
Shouldn't this also lead to diabetes?
So, can alcoholism through these (or other) mechanisms lead to diabetes?
asked Jan 08, 2010 at 09:23AM in Diabetes
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5Votesanswered Jan 08, 2010 at 12:19PMThe problem that you are posing in a question is an assumption on your part that somehow equates two different criteria (Alcoholism and Obesity) leading to Type 2 Diabetes.
Alcoholism does create a Fatty Liver and will in turn cause hepatoxicity leading to Hepatitis, then Coma and eventual Death. Having worked in various Medical Units, I have seen this in both Vry thin individuals and in obese patients as well who were Alcoholic.
As for Obesity, it does create Ectopic Fat.......which will cover the Heart, Liver, Kidneys leading to inflammation of these organs as well as Free Radicals and further destruction within the Body as a whole. There is a lowering of glucose values in persons who are alcoholic and this in turn releases counter-regulatory hormones such as Epinephrine that will compensate for that loss.
So, in my opinion,,,,,,,Alcoholism does not lead to T2D. -
1Votesanswered Jan 08, 2010 at 07:32PMJesper Hessius.
Yes, Alcoholism can cause Inflammation to the Pancreas leading to Acute Pancreatitis which can be treated with the person recovering fully and tissue cell function restored.
But with Chronic Pancreatitis due to excessive alcohol consumption..........the organ
will fail leading to Diabetes.
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The content on or accessible through Medpedia.com is for informational purposes only. Medpedia is not a substitute for professional advice or expert medical services from a qualified health professional.
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Just to clarify I just wanted to compare the physiological effects of suffering from obesity and of suffering from alcoholism and noticed, what I thought to be, some similarities in the metabolic effects between the two.
But wouldn't alcoholism also cause pancreatitis, which in turn could cause diabetes?
I found this article: http://care.diabetesjournals.org/content/26/10/2785.full
"The results of this study suggested that moderate alcohol consumption may reduce the risk of type 2 diabetes. On the other hand, binge drinking and high alco