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(Cardiology/Heart Disease)

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    answered Mar 02, 2010 at 02:16PM
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    Dear Sir,
    Your question is very pointed. The common thread in these four etiologies is that they all cause microvasular disease. Myocardial Infarction (heart attack) is caused by a lack of oxygen to the heart muscle (myocardium). This lack of oxygen (ischemia) is caused by either a blockage of the cardiac vessel supplying the heart muscle or due to contraction of these vessels. High blood pressure (hypertension, HTN) over time will make the vessels hard and non-compliant to changes required due to stress and oxygen demand. At some point, the vessels do not dilate to increase blood supply and with increased pressure, the walls of the vessels are unable to allow oxygen transport into the myocardium. Elevated cholesterol (hyperlipidemia, hypercholesterolemia) progresses to a state called atherosclerotic cardiovascular disease in which the arteries become hard (sclerosis), narrowed by cholesterol deposits (atherotic plaque) and eventually this can norrow to the point where there is no blow flow in that part of the vessel. Oxygen is neither delivered to that part of the heart nor beyond that point. Diabetes acts on the small vessels of the body (and the heart) in a very similar way as athersclerotic heart disease, plus with elevated blood glucose, the blood becomes very thick (like catsup) and the delivery of oxygen is further deminished. Tobacco (the big killer) is a very potent vasoconstrictor and narrows the blood vessels. It also contributes to a whole trove of other heath issues, but most critical to your question, is that it decreases the oxygen exchange between the lungs and vascular system. There is less oxygen available to all the tissues, including the heart.

    So, the person who has HTN, elevated lipids, diabetes and is a smoker has pretty much seal her/his fate.
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