Medpedia

Girish J Kotwal Ph.D.

President, Kotwal Bioconsulting, LLC

Louisville, KY

Specialties and Interests

  • Acquired Immunodeficiency Syndrome, 
  • Alzheimer Disease, 
  • Anti-Inflammatory Agents, Non-Steroidal, 
  • Microbiology, 
  • Molecular Biology, 
  • Virology, 
  • Immunology

Education

Universities

McMaster University

Ph.D., Biochemistry

Mentors

Bernard Moss, MD, Ph.D.

Post Doctoral Mentor 1984-1990. Dr. Moss is a member of the US National Academy of Science and Chief of Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, MD, USA

Hara P. Ghosh

Doctoral mentor 1979-1984. Dr. Hara P. Ghosh is currently Emeritus Professor, Department of Biochemistry, McMaster University. Hamilton, Ont. Canada

Publications

Articles

"Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood."

Infection and immunity
Vol. 77 - 2009;
PubMed ID: 19047409

"Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus."

PLoS ONE
Vol. 3 - 2008;
PubMed ID: 18830408

"Intracranial administration of vaccinia virus complement control protein in Mo/Hu APPswe PS1dE9 transgenic mice at an early age shows enhanced performance at a later age using a cheese board maze test."

Biogerontology
Vol. 9 - 2008;
PubMed ID: 18679819

"Early detection of memory deficits and memory improvement with vaccinia virus complement control protein in an Alzheimer's disease model."

Behavioural brain research
Vol. 192 - 2008;
PubMed ID: 18490064

"Genetic diversity-independent neutralization of pandemic viruses (e.g. HIV), potentially pandemic (e.g. H5N1 strain of influenza) and carcinogenic (e.g. HBV and HCV) viruses and possible agents of bioterrorism (variola) by enveloped virus neutralizing compounds (EVNCs)."

Vaccine
Vol. 26 - 2008;
PubMed ID: 18241960

"Vaccinia virus complement control protein significantly improves sensorimotor function recovery after severe head trauma."

Brain research
Vol. 1153 - 2007;
PubMed ID: 17467672

"Purification of 3 monomeric monocot mannose-binding lectins and their evaluation for antipoxviral activity: potential applications in multiple viral diseases caused by enveloped viruses."

Biochemistry and cell biology = Biochimie et biologie cellulaire
Vol. 85 - 2007;
PubMed ID: 17464348

"Antiviral activity of purified human breast milk mucin."

Neonatology
Vol. 92 - 2007;
PubMed ID: 17361093

"Humanized recombinant vaccinia virus complement control protein (hrVCP) with three amino acid changes, H98Y, E102K, and E120K creating an additional putative heparin binding site, is 100-fold more active than rVCP in blocking both classical and alternative complement pathways."

Annals of the New York Academy of Sciences
Vol. 1056 - 2006;
PubMed ID: 16387681

"Cloning and expression of a functionally active truncated N-glycosylated KSHV ORF4/KCP/kaposica in the methylotrophic yeast Pichia pastoris."

Annals of the New York Academy of Sciences
Vol. 1056 - 2006;
PubMed ID: 16387704
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Disclosure or Conflict of Interest

Also Founder President and CEO, InflaMed Inc.Holding major equity

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