Girish J Kotwal Ph.D.
President, Kotwal Bioconsulting, LLC
Louisville, KY
Specialties and Interests
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Acquired Immunodeficiency Syndrome,
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Alzheimer Disease,
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Anti-Inflammatory Agents, Non-Steroidal,
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Microbiology,
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Molecular Biology,
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Virology,
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Immunology
Education
Universities
McMaster University
Ph.D., Biochemistry
Mentors
Bernard Moss, MD, Ph.D.
Hara P. Ghosh
Publications
Articles
"Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood."
"Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus."
"Intracranial administration of vaccinia virus complement control protein in Mo/Hu APPswe PS1dE9 transgenic mice at an early age shows enhanced performance at a later age using a cheese board maze test."
"Early detection of memory deficits and memory improvement with vaccinia virus complement control protein in an Alzheimer's disease model."
"Genetic diversity-independent neutralization of pandemic viruses (e.g. HIV), potentially pandemic (e.g. H5N1 strain of influenza) and carcinogenic (e.g. HBV and HCV) viruses and possible agents of bioterrorism (variola) by enveloped virus neutralizing compounds (EVNCs)."
"Vaccinia virus complement control protein significantly improves sensorimotor function recovery after severe head trauma."
"Purification of 3 monomeric monocot mannose-binding lectins and their evaluation for antipoxviral activity: potential applications in multiple viral diseases caused by enveloped viruses."
"Antiviral activity of purified human breast milk mucin."
"Humanized recombinant vaccinia virus complement control protein (hrVCP) with three amino acid changes, H98Y, E102K, and E120K creating an additional putative heparin binding site, is 100-fold more active than rVCP in blocking both classical and alternative complement pathways."
"Cloning and expression of a functionally active truncated N-glycosylated KSHV ORF4/KCP/kaposica in the methylotrophic yeast Pichia pastoris."
Disclosure or Conflict of Interest
Also Founder President and CEO, InflaMed Inc.Holding major equity

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